A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes

A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes

Carbon monoxide (CO) can prevent cell and tissue damage by restoring redox homeostasis and counteracting inflammation. CO-releasing molecules (CORMs) can release a controlled amount of CO to cells and are emerging as a safer therapeutic alternative to delivery of CO in vivo. Sustained oxidative stre...

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Bibliographic Details
Main Authors: Federico Appetecchia, Sara Consalvi, Emanuela Berrino, Marialucia Gallorini, Arianna Granese, Cristina Campestre, Simone Carradori, Mariangela Biava, Giovanna Poce
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
CO-releasing molecules
tenocytes
PGE<sub>2</sub>
1,5-diarylpyrrole
1,5-diarylpyrazole
carbon monoxide
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/b2ff742f5df44003bbfc475b14a2710c
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https://doaj.org/article/b2ff742f5df44003bbfc475b14a2710c

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