Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis

Exosomes are small vesicles derived from cells used as cell-to-cell communication goods in numerous diseases including tumorigenesis, neurological diseases, cardiovascular diseases and other diseases. Circular RNAs (circRNAs) are an innovative constituent of non-coding endogenous RNAs generated thro...

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Autores principales:	Kearabetsoe Matseliso Molibeli, Rong Hu, Yuze Liu, Dehui Xiong, Lijun Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	exosomes exosomal circRNA biomarker miRNA sponge diagnosis therapeutic target Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b303d9015f6c4160979def3dd510042d
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spelling	oai:doaj.org-article:b303d9015f6c4160979def3dd510042d2021-11-30T18:11:30ZPotential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis2296-889X10.3389/fmolb.2021.769832https://doaj.org/article/b303d9015f6c4160979def3dd510042d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.769832/fullhttps://doaj.org/toc/2296-889XExosomes are small vesicles derived from cells used as cell-to-cell communication goods in numerous diseases including tumorigenesis, neurological diseases, cardiovascular diseases and other diseases. Circular RNAs (circRNAs) are an innovative constituent of non-coding endogenous RNAs generated through backsplicing, catalyzed by RNA polymerase Ⅱ. These non-coding RNAs have been suggested to control gene expression through miRNA sponging, RNA-binding protein regulation and translational capabilities. Genome-wide RNA sequence analyses observed that circRNAs were stably improved in exosomes in association to parental cells. Little attention has been dedicated to exosomal circRNAs (exo-circRNAs). However, research has demonstrated that exo-circRNAs may have important regulatory functions because of their stability in cells and within exosomes. If well understood, the precise roles and mechanisms of exo-circRNAs might surge the impending clinical applications of these molecules as markers in the identification, prediction and treatment of various diseases. In this review, we outline recent findings regarding exo-circRNAs which includes their functions and highlights their potential applications and therapeutic targets in human diseases.Kearabetsoe Matseliso MolibeliKearabetsoe Matseliso MolibeliRong HuRong HuYuze LiuYuze LiuDehui XiongDehui XiongLijun TangLijun TangFrontiers Media S.A.articleexosomesexosomal circRNAbiomarkermiRNA spongediagnosistherapeutic targetBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes exosomal circRNA biomarker miRNA sponge diagnosis therapeutic target Biology (General) QH301-705.5
spellingShingle	exosomes exosomal circRNA biomarker miRNA sponge diagnosis therapeutic target Biology (General) QH301-705.5 Kearabetsoe Matseliso Molibeli Kearabetsoe Matseliso Molibeli Rong Hu Rong Hu Yuze Liu Yuze Liu Dehui Xiong Dehui Xiong Lijun Tang Lijun Tang Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
description	Exosomes are small vesicles derived from cells used as cell-to-cell communication goods in numerous diseases including tumorigenesis, neurological diseases, cardiovascular diseases and other diseases. Circular RNAs (circRNAs) are an innovative constituent of non-coding endogenous RNAs generated through backsplicing, catalyzed by RNA polymerase Ⅱ. These non-coding RNAs have been suggested to control gene expression through miRNA sponging, RNA-binding protein regulation and translational capabilities. Genome-wide RNA sequence analyses observed that circRNAs were stably improved in exosomes in association to parental cells. Little attention has been dedicated to exosomal circRNAs (exo-circRNAs). However, research has demonstrated that exo-circRNAs may have important regulatory functions because of their stability in cells and within exosomes. If well understood, the precise roles and mechanisms of exo-circRNAs might surge the impending clinical applications of these molecules as markers in the identification, prediction and treatment of various diseases. In this review, we outline recent findings regarding exo-circRNAs which includes their functions and highlights their potential applications and therapeutic targets in human diseases.
format	article
author	Kearabetsoe Matseliso Molibeli Kearabetsoe Matseliso Molibeli Rong Hu Rong Hu Yuze Liu Yuze Liu Dehui Xiong Dehui Xiong Lijun Tang Lijun Tang
author_facet	Kearabetsoe Matseliso Molibeli Kearabetsoe Matseliso Molibeli Rong Hu Rong Hu Yuze Liu Yuze Liu Dehui Xiong Dehui Xiong Lijun Tang Lijun Tang
author_sort	Kearabetsoe Matseliso Molibeli
title	Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
title_short	Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
title_full	Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
title_fullStr	Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
title_full_unstemmed	Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis
title_sort	potential clinical applications of exosomal circular rnas: more than diagnosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b303d9015f6c4160979def3dd510042d
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Potential Clinical Applications of Exosomal Circular RNAs: More than Diagnosis

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