A multiplexable TALE-based binary expression system for in vivo cellular interaction studies

Binary expression systems enable researchers to deliver loss-of-function or gain-of-function transgenes with spatial-temporal resolution in vivo. Here, the authors present a programmable TALE-based system for multiplexed orthogonal activation of transgenes in Drosophila.

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Detalles Bibliográficos
Autores principales: Markus Toegel, Ghows Azzam, Eunice Y. Lee, David J. H. F. Knapp, Ying Tan, Ming Fa, Tudor A. Fulga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b30571d62f584df9bcba980fa93d1565
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Descripción
Sumario:Binary expression systems enable researchers to deliver loss-of-function or gain-of-function transgenes with spatial-temporal resolution in vivo. Here, the authors present a programmable TALE-based system for multiplexed orthogonal activation of transgenes in Drosophila.