Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and natural killer T [NKT] cells) display several...

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Autores principales:	Stoyan Ivanov, Christophe Paget, François Trottein
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b3080d11193c4c9386eb54feae2f5f81
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spelling	oai:doaj.org-article:b3080d11193c4c9386eb54feae2f5f812021-11-25T05:45:57ZRole of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.1553-73661553-737410.1371/journal.ppat.1004300https://doaj.org/article/b3080d11193c4c9386eb54feae2f5f812014-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1004300https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and natural killer T [NKT] cells) display several innate cell-like features and are rapidly activated by the recognition of conserved, stress-induced, self, and microbial ligands. Here, we review the role of non-conventional T cells during respiratory infections, with a particular focus on the encapsulated extracellular pathogen Streptococcus pneumoniae, the leading cause of bacterial pneumonia worldwide. We consider whether MAIT cells, γδ T cells, and NKT cells might offer opportunities for preventing and/or treating human pneumococcus infections.Stoyan IvanovChristophe PagetFrançois TrotteinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 10, p e1004300 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Stoyan Ivanov Christophe Paget François Trottein Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
description	Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and natural killer T [NKT] cells) display several innate cell-like features and are rapidly activated by the recognition of conserved, stress-induced, self, and microbial ligands. Here, we review the role of non-conventional T cells during respiratory infections, with a particular focus on the encapsulated extracellular pathogen Streptococcus pneumoniae, the leading cause of bacterial pneumonia worldwide. We consider whether MAIT cells, γδ T cells, and NKT cells might offer opportunities for preventing and/or treating human pneumococcus infections.
format	article
author	Stoyan Ivanov Christophe Paget François Trottein
author_facet	Stoyan Ivanov Christophe Paget François Trottein
author_sort	Stoyan Ivanov
title	Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
title_short	Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
title_full	Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
title_fullStr	Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
title_full_unstemmed	Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.
title_sort	role of non-conventional t lymphocytes in respiratory infections: the case of the pneumococcus.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b3080d11193c4c9386eb54feae2f5f81
work_keys_str_mv	AT stoyanivanov roleofnonconventionaltlymphocytesinrespiratoryinfectionsthecaseofthepneumococcus AT christophepaget roleofnonconventionaltlymphocytesinrespiratoryinfectionsthecaseofthepneumococcus AT francoistrottein roleofnonconventionaltlymphocytesinrespiratoryinfectionsthecaseofthepneumococcus
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Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

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