Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes

Ultrasmall microelectrode arrays have the potential to improve the spatial resolution of microstimulation. Carbon fiber (CF) microelectrodes with cross-sections of less than 8 μm have been demonstrated to penetrate cortical tissue and evoke minimal scarring in chronic implant tests. In this study, w...

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Autores principales:	Elena della Valle, Beomseo Koo, Paras R. Patel, Quentin Whitsitt, Erin K. Purcell, Cynthia A. Chestek, James D. Weiland
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carbon fiber microelectrode (CFME) PtIr coating microstimulation in vivo stimulation in vitro stimulation Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/b30964da9f2e4509b6268f43b0ccc34e
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spelling	oai:doaj.org-article:b30964da9f2e4509b6268f43b0ccc34e2021-12-02T11:50:09ZElectrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes2673-301310.3389/fnano.2021.782883https://doaj.org/article/b30964da9f2e4509b6268f43b0ccc34e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnano.2021.782883/fullhttps://doaj.org/toc/2673-3013Ultrasmall microelectrode arrays have the potential to improve the spatial resolution of microstimulation. Carbon fiber (CF) microelectrodes with cross-sections of less than 8 μm have been demonstrated to penetrate cortical tissue and evoke minimal scarring in chronic implant tests. In this study, we investigate the stability and performance of neural stimulation electrodes comprised of electrodeposited platinum-iridium (PtIr) on carbon fibers. We conducted pulse testing and characterized charge injection in vitro and recorded voltage transients in vitro and in vivo. Standard electrochemical measurements (impedance spectroscopy and cyclic voltammetry) and visual inspection (scanning electron microscopy) were used to assess changes due to pulsing. Similar to other studies, the application of pulses caused a decrease in impedance and a reduction in voltage transients, but analysis of the impedance data suggests that these changes are due to surface modification and not permanent changes to the electrode. Comparison of scanning electron microscope images before and after pulse testing confirmed electrode stability.Elena della ValleElena della ValleBeomseo KooBeomseo KooParas R. PatelParas R. PatelQuentin WhitsittErin K. PurcellCynthia A. ChestekCynthia A. ChestekCynthia A. ChestekCynthia A. ChestekCynthia A. ChestekJames D. WeilandJames D. WeilandJames D. WeilandFrontiers Media S.A.articlecarbon fiber microelectrode (CFME)PtIr coatingmicrostimulationin vivo stimulationin vitro stimulationChemical technologyTP1-1185ENFrontiers in Nanotechnology, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon fiber microelectrode (CFME) PtIr coating microstimulation in vivo stimulation in vitro stimulation Chemical technology TP1-1185
spellingShingle	carbon fiber microelectrode (CFME) PtIr coating microstimulation in vivo stimulation in vitro stimulation Chemical technology TP1-1185 Elena della Valle Elena della Valle Beomseo Koo Beomseo Koo Paras R. Patel Paras R. Patel Quentin Whitsitt Erin K. Purcell Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek James D. Weiland James D. Weiland James D. Weiland Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
description	Ultrasmall microelectrode arrays have the potential to improve the spatial resolution of microstimulation. Carbon fiber (CF) microelectrodes with cross-sections of less than 8 μm have been demonstrated to penetrate cortical tissue and evoke minimal scarring in chronic implant tests. In this study, we investigate the stability and performance of neural stimulation electrodes comprised of electrodeposited platinum-iridium (PtIr) on carbon fibers. We conducted pulse testing and characterized charge injection in vitro and recorded voltage transients in vitro and in vivo. Standard electrochemical measurements (impedance spectroscopy and cyclic voltammetry) and visual inspection (scanning electron microscopy) were used to assess changes due to pulsing. Similar to other studies, the application of pulses caused a decrease in impedance and a reduction in voltage transients, but analysis of the impedance data suggests that these changes are due to surface modification and not permanent changes to the electrode. Comparison of scanning electron microscope images before and after pulse testing confirmed electrode stability.
format	article
author	Elena della Valle Elena della Valle Beomseo Koo Beomseo Koo Paras R. Patel Paras R. Patel Quentin Whitsitt Erin K. Purcell Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek James D. Weiland James D. Weiland James D. Weiland
author_facet	Elena della Valle Elena della Valle Beomseo Koo Beomseo Koo Paras R. Patel Paras R. Patel Quentin Whitsitt Erin K. Purcell Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek Cynthia A. Chestek James D. Weiland James D. Weiland James D. Weiland
author_sort	Elena della Valle
title	Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
title_short	Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
title_full	Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
title_fullStr	Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
title_full_unstemmed	Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
title_sort	electrodeposited platinum iridium enables microstimulation with carbon fiber electrodes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b30964da9f2e4509b6268f43b0ccc34e
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Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes

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