Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis

Abstract The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE)...

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Autores principales:	Chunping Liu, Shuntao Wang, Wen Zeng, Yawen Guo, Zeming Liu, Tao Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b30b1238f5134338a460d26a98fb4ef3
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spelling	oai:doaj.org-article:b30b1238f5134338a460d26a98fb4ef32021-12-02T11:52:31ZTotal tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis10.1038/s41598-017-02165-62045-2322https://doaj.org/article/b30b1238f5134338a460d26a98fb4ef32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02165-6https://doaj.org/toc/2045-2322Abstract The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE), local infiltration, central lymph node metastasis (LNM), and prognosis. Consecutive patients (n = 1102) were identified and the proportions of LNM, ETE, and local infiltration were similar between PTCs with a unifocal tumour diameter >1 cm and ≤2 cm and PTMCs with a multifocal TTD >1 cm and ≤2 cm. The proportions of LNM, ETE, and local infiltration were also similar between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD ≤1 cm. However, when comparing PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm, significant differences were observed. In the Kaplan-Meier analysis, significant differences were observed between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm and multifocal TTD ≤1 cm vs. multifocal TTD >1 cm. Accordingly, TTD may represent a more accurate criterion for tumour size of PTCs and should be considered in the revised AJCC staging system.Chunping LiuShuntao WangWen ZengYawen GuoZeming LiuTao HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chunping Liu Shuntao Wang Wen Zeng Yawen Guo Zeming Liu Tao Huang Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
description	Abstract The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE), local infiltration, central lymph node metastasis (LNM), and prognosis. Consecutive patients (n = 1102) were identified and the proportions of LNM, ETE, and local infiltration were similar between PTCs with a unifocal tumour diameter >1 cm and ≤2 cm and PTMCs with a multifocal TTD >1 cm and ≤2 cm. The proportions of LNM, ETE, and local infiltration were also similar between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD ≤1 cm. However, when comparing PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm, significant differences were observed. In the Kaplan-Meier analysis, significant differences were observed between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm and multifocal TTD ≤1 cm vs. multifocal TTD >1 cm. Accordingly, TTD may represent a more accurate criterion for tumour size of PTCs and should be considered in the revised AJCC staging system.
format	article
author	Chunping Liu Shuntao Wang Wen Zeng Yawen Guo Zeming Liu Tao Huang
author_facet	Chunping Liu Shuntao Wang Wen Zeng Yawen Guo Zeming Liu Tao Huang
author_sort	Chunping Liu
title	Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
title_short	Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
title_full	Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
title_fullStr	Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
title_full_unstemmed	Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
title_sort	total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b30b1238f5134338a460d26a98fb4ef3
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Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis

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