Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-penetrating peptide iRGD to deliver siRNA against STA...

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Autores principales:	Jason V. Gregory, Padma Kadiyala, Robert Doherty, Melissa Cadena, Samer Habeel, Erkki Ruoslahti, Pedro R. Lowenstein, Maria G. Castro, Joerg Lahann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b78
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spelling	oai:doaj.org-article:b30c04bdef1f4073bda6bbf46a097b782021-12-02T14:41:01ZSystemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy10.1038/s41467-020-19225-72041-1723https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b782020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19225-7https://doaj.org/toc/2041-1723The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-penetrating peptide iRGD to deliver siRNA against STAT3 and report improved survival in a mouse model of GBM.Jason V. GregoryPadma KadiyalaRobert DohertyMelissa CadenaSamer HabeelErkki RuoslahtiPedro R. LowensteinMaria G. CastroJoerg LahannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason V. Gregory Padma Kadiyala Robert Doherty Melissa Cadena Samer Habeel Erkki Ruoslahti Pedro R. Lowenstein Maria G. Castro Joerg Lahann Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
description	The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-penetrating peptide iRGD to deliver siRNA against STAT3 and report improved survival in a mouse model of GBM.
format	article
author	Jason V. Gregory Padma Kadiyala Robert Doherty Melissa Cadena Samer Habeel Erkki Ruoslahti Pedro R. Lowenstein Maria G. Castro Joerg Lahann
author_facet	Jason V. Gregory Padma Kadiyala Robert Doherty Melissa Cadena Samer Habeel Erkki Ruoslahti Pedro R. Lowenstein Maria G. Castro Joerg Lahann
author_sort	Jason V. Gregory
title	Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
title_short	Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
title_full	Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
title_fullStr	Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
title_full_unstemmed	Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
title_sort	systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b78
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Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

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