Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

Wiskott–Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency syndrome. Here, the authors show that loss of WAS gene in dendritic cells results in increased activity of Rac2, increase of phagosomal pH, and more efficient cross-presentation.

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Autores principales:	Marisa A. P. Baptista, Marton Keszei, Mariana Oliveira, Karen K. S. Sunahara, John Andersson, Carin I. M. Dahlberg, Austen J. Worth, Agne Liedén, I-Chun Kuo, Robert P. A. Wallin, Scott B. Snapper, Liv Eidsmo, Annika Scheynius, Mikael C. I. Karlsson, Gerben Bouma, Siobhan O. Burns, Mattias N. E. Forsell, Adrian J. Thrasher, Susanne Nylén, Lisa S. Westerberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b30cb5531b534a4c9f3e0c5bebf69da8
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spelling	oai:doaj.org-article:b30cb5531b534a4c9f3e0c5bebf69da82021-12-02T17:32:49ZDeletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells10.1038/ncomms121752041-1723https://doaj.org/article/b30cb5531b534a4c9f3e0c5bebf69da82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12175https://doaj.org/toc/2041-1723Wiskott–Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency syndrome. Here, the authors show that loss of WAS gene in dendritic cells results in increased activity of Rac2, increase of phagosomal pH, and more efficient cross-presentation.Marisa A. P. BaptistaMarton KeszeiMariana OliveiraKaren K. S. SunaharaJohn AnderssonCarin I. M. DahlbergAusten J. WorthAgne LiedénI-Chun KuoRobert P. A. WallinScott B. SnapperLiv EidsmoAnnika ScheyniusMikael C. I. KarlssonGerben BoumaSiobhan O. BurnsMattias N. E. ForsellAdrian J. ThrasherSusanne NylénLisa S. WesterbergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marisa A. P. Baptista Marton Keszei Mariana Oliveira Karen K. S. Sunahara John Andersson Carin I. M. Dahlberg Austen J. Worth Agne Liedén I-Chun Kuo Robert P. A. Wallin Scott B. Snapper Liv Eidsmo Annika Scheynius Mikael C. I. Karlsson Gerben Bouma Siobhan O. Burns Mattias N. E. Forsell Adrian J. Thrasher Susanne Nylén Lisa S. Westerberg Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
description	Wiskott–Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency syndrome. Here, the authors show that loss of WAS gene in dendritic cells results in increased activity of Rac2, increase of phagosomal pH, and more efficient cross-presentation.
format	article
author	Marisa A. P. Baptista Marton Keszei Mariana Oliveira Karen K. S. Sunahara John Andersson Carin I. M. Dahlberg Austen J. Worth Agne Liedén I-Chun Kuo Robert P. A. Wallin Scott B. Snapper Liv Eidsmo Annika Scheynius Mikael C. I. Karlsson Gerben Bouma Siobhan O. Burns Mattias N. E. Forsell Adrian J. Thrasher Susanne Nylén Lisa S. Westerberg
author_facet	Marisa A. P. Baptista Marton Keszei Mariana Oliveira Karen K. S. Sunahara John Andersson Carin I. M. Dahlberg Austen J. Worth Agne Liedén I-Chun Kuo Robert P. A. Wallin Scott B. Snapper Liv Eidsmo Annika Scheynius Mikael C. I. Karlsson Gerben Bouma Siobhan O. Burns Mattias N. E. Forsell Adrian J. Thrasher Susanne Nylén Lisa S. Westerberg
author_sort	Marisa A. P. Baptista
title	Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
title_short	Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
title_full	Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
title_fullStr	Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
title_full_unstemmed	Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
title_sort	deletion of wiskott–aldrich syndrome protein triggers rac2 activity and increased cross-presentation by dendritic cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b30cb5531b534a4c9f3e0c5bebf69da8
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Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

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