The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder

Abstract Brain-derived neurotrophic factor (BDNF), a key peptide in neurocognitive development, has been reported to be elevated in the serum of children with autism spectrum disorder (ASD). In a few studies, however, no differences or the converse have been documented. As a secondary analysis of a...

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Autores principales:	Cristan A. Farmer, Audrey E. Thurm, Bianca Honnekeri, Paul Kim, Susan E. Swedo, Joan C. Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b30d12340fc9469184346d72304286de
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spelling	oai:doaj.org-article:b30d12340fc9469184346d72304286de2021-12-02T18:50:48ZThe contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder10.1038/s41598-021-97367-42045-2322https://doaj.org/article/b30d12340fc9469184346d72304286de2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97367-4https://doaj.org/toc/2045-2322Abstract Brain-derived neurotrophic factor (BDNF), a key peptide in neurocognitive development, has been reported to be elevated in the serum of children with autism spectrum disorder (ASD). In a few studies, however, no differences or the converse have been documented. As a secondary analysis of a natural history study, we examined differences in ELISA serum BDNF between a group of children aged 1 to 9 years (69% white) with ASD (n = 94) and those with typical development (n = 52) or non-ASD developmental delay (n = 21), while accounting for the potential confounding effects of platelet quantity. Platelet counts were measured within 4 h of blood draw using an automated cell counter. Taqman single nucleotide polymorphism (SNP) assays were used to genotype 11 SNPs within the BDNF locus. Unadjusted mean BDNF concentration was higher in children with ASD than in children with typical development (standardized mean difference = 0.23; 95% CI 0.07, 0.38), but not children with non-ASD developmental delay. The magnitude of this difference was reduced after adjusting for platelet count (standardized mean difference = 0.18; 95% CI 0.02, 0.33). Although some BDNF SNPs were related to BDNF concentration, the distributions of these genotypes did not differ across diagnostic groups. This study replicates previous work suggesting that average serum BDNF concentration is higher in ASD compared to typical development, and extends that work by highlighting the potentially confounding role of platelet counts. The etiology of platelet count differences warrants further elucidation. Nonetheless, our results suggest that elevation in BDNF may be partially explained by higher platelet counts in children with ASD, an association that should be considered in future analysis and interpretation. Registration: NCT00298246Cristan A. FarmerAudrey E. ThurmBianca HonnekeriPaul KimSusan E. SwedoJoan C. HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristan A. Farmer Audrey E. Thurm Bianca Honnekeri Paul Kim Susan E. Swedo Joan C. Han The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
description	Abstract Brain-derived neurotrophic factor (BDNF), a key peptide in neurocognitive development, has been reported to be elevated in the serum of children with autism spectrum disorder (ASD). In a few studies, however, no differences or the converse have been documented. As a secondary analysis of a natural history study, we examined differences in ELISA serum BDNF between a group of children aged 1 to 9 years (69% white) with ASD (n = 94) and those with typical development (n = 52) or non-ASD developmental delay (n = 21), while accounting for the potential confounding effects of platelet quantity. Platelet counts were measured within 4 h of blood draw using an automated cell counter. Taqman single nucleotide polymorphism (SNP) assays were used to genotype 11 SNPs within the BDNF locus. Unadjusted mean BDNF concentration was higher in children with ASD than in children with typical development (standardized mean difference = 0.23; 95% CI 0.07, 0.38), but not children with non-ASD developmental delay. The magnitude of this difference was reduced after adjusting for platelet count (standardized mean difference = 0.18; 95% CI 0.02, 0.33). Although some BDNF SNPs were related to BDNF concentration, the distributions of these genotypes did not differ across diagnostic groups. This study replicates previous work suggesting that average serum BDNF concentration is higher in ASD compared to typical development, and extends that work by highlighting the potentially confounding role of platelet counts. The etiology of platelet count differences warrants further elucidation. Nonetheless, our results suggest that elevation in BDNF may be partially explained by higher platelet counts in children with ASD, an association that should be considered in future analysis and interpretation. Registration: NCT00298246
format	article
author	Cristan A. Farmer Audrey E. Thurm Bianca Honnekeri Paul Kim Susan E. Swedo Joan C. Han
author_facet	Cristan A. Farmer Audrey E. Thurm Bianca Honnekeri Paul Kim Susan E. Swedo Joan C. Han
author_sort	Cristan A. Farmer
title	The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
title_short	The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
title_full	The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
title_fullStr	The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
title_full_unstemmed	The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
title_sort	contribution of platelets to peripheral bdnf elevation in children with autism spectrum disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b30d12340fc9469184346d72304286de
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The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder

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