Overcoming MCL-1-driven adaptive resistance to targeted therapies

Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clini...

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Autor principal:	Kris C. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3104b61e16b45ff87d587459438569d
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spelling	oai:doaj.org-article:b3104b61e16b45ff87d587459438569d2021-12-02T15:33:50ZOvercoming MCL-1-driven adaptive resistance to targeted therapies10.1038/s41467-020-14392-z2041-1723https://doaj.org/article/b3104b61e16b45ff87d587459438569d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14392-zhttps://doaj.org/toc/2041-1723Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clinic.Kris C. WoodNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kris C. Wood Overcoming MCL-1-driven adaptive resistance to targeted therapies
description	Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clinic.
format	article
author	Kris C. Wood
author_facet	Kris C. Wood
author_sort	Kris C. Wood
title	Overcoming MCL-1-driven adaptive resistance to targeted therapies
title_short	Overcoming MCL-1-driven adaptive resistance to targeted therapies
title_full	Overcoming MCL-1-driven adaptive resistance to targeted therapies
title_fullStr	Overcoming MCL-1-driven adaptive resistance to targeted therapies
title_full_unstemmed	Overcoming MCL-1-driven adaptive resistance to targeted therapies
title_sort	overcoming mcl-1-driven adaptive resistance to targeted therapies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b3104b61e16b45ff87d587459438569d
work_keys_str_mv	AT kriscwood overcomingmcl1drivenadaptiveresistancetotargetedtherapies
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Overcoming MCL-1-driven adaptive resistance to targeted therapies

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