Overcoming MCL-1-driven adaptive resistance to targeted therapies
Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clini...
Enregistré dans:
Auteur principal: | Kris C. Wood |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/b3104b61e16b45ff87d587459438569d |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma
par: Dana S. Neel, et autres
Publié: (2017) -
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically
par: Enkhtsetseg Munkhbaatar, et autres
Publié: (2020) -
Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
par: Moiez Ali, et autres
Publié: (2017) -
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
par: Matthew J. Sale, et autres
Publié: (2019) -
Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
par: Xufeng Cen, et autres
Publié: (2020)