Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing th...

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Autores principales:	Wei Huang, Yuliang Feng, Jialiang Liang, Hao Yu, Cheng Wang, Boyu Wang, Mingyang Wang, Lin Jiang, Wei Meng, Wenfeng Cai, Mario Medvedovic, Jenny Chen, Christian Paul, W. Sean Davidson, Sakthivel Sadayappan, Peter J. Stambrook, Xi-Yong Yu, Yigang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b31199b519cc42139b0e79ff4459abd5
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spelling	oai:doaj.org-article:b31199b519cc42139b0e79ff4459abd52021-12-02T17:31:12ZLoss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration10.1038/s41467-018-03019-z2041-1723https://doaj.org/article/b31199b519cc42139b0e79ff4459abd52018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03019-zhttps://doaj.org/toc/2041-1723During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.Wei HuangYuliang FengJialiang LiangHao YuCheng WangBoyu WangMingyang WangLin JiangWei MengWenfeng CaiMario MedvedovicJenny ChenChristian PaulW. Sean DavidsonSakthivel SadayappanPeter J. StambrookXi-Yong YuYigang WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Huang Yuliang Feng Jialiang Liang Hao Yu Cheng Wang Boyu Wang Mingyang Wang Lin Jiang Wei Meng Wenfeng Cai Mario Medvedovic Jenny Chen Christian Paul W. Sean Davidson Sakthivel Sadayappan Peter J. Stambrook Xi-Yong Yu Yigang Wang Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
description	During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.
format	article
author	Wei Huang Yuliang Feng Jialiang Liang Hao Yu Cheng Wang Boyu Wang Mingyang Wang Lin Jiang Wei Meng Wenfeng Cai Mario Medvedovic Jenny Chen Christian Paul W. Sean Davidson Sakthivel Sadayappan Peter J. Stambrook Xi-Yong Yu Yigang Wang
author_facet	Wei Huang Yuliang Feng Jialiang Liang Hao Yu Cheng Wang Boyu Wang Mingyang Wang Lin Jiang Wei Meng Wenfeng Cai Mario Medvedovic Jenny Chen Christian Paul W. Sean Davidson Sakthivel Sadayappan Peter J. Stambrook Xi-Yong Yu Yigang Wang
author_sort	Wei Huang
title	Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
title_short	Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
title_full	Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
title_fullStr	Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
title_full_unstemmed	Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
title_sort	loss of microrna-128 promotes cardiomyocyte proliferation and heart regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b31199b519cc42139b0e79ff4459abd5
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_version_	1718380693757624320

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

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