A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways
Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype.
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Nature Portfolio
2016
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oai:doaj.org-article:b31366b622e74db0ba44d725ba9596812021-12-02T14:39:54ZA regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways10.1038/ncomms128852041-1723https://doaj.org/article/b31366b622e74db0ba44d725ba9596812016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12885https://doaj.org/toc/2041-1723Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype.Tianzhi HuangAngel A. AlvarezRajendra P. PangeniCraig M. HorbinskiSongjian LuSung-Hak KimC. David JamesJeffery J. RaizerJohn A. KesslerCameron W. BrenannErik P. SulmanGaetano FinocchiaroMing TanRyo NishikawaXinghua LuIchiro NakanoBo HuShi-Yuan ChengNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tianzhi Huang Angel A. Alvarez Rajendra P. Pangeni Craig M. Horbinski Songjian Lu Sung-Hak Kim C. David James Jeffery J. Raizer John A. Kessler Cameron W. Brenann Erik P. Sulman Gaetano Finocchiaro Ming Tan Ryo Nishikawa Xinghua Lu Ichiro Nakano Bo Hu Shi-Yuan Cheng A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| description |
Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype. |
| format |
article |
| author |
Tianzhi Huang Angel A. Alvarez Rajendra P. Pangeni Craig M. Horbinski Songjian Lu Sung-Hak Kim C. David James Jeffery J. Raizer John A. Kessler Cameron W. Brenann Erik P. Sulman Gaetano Finocchiaro Ming Tan Ryo Nishikawa Xinghua Lu Ichiro Nakano Bo Hu Shi-Yuan Cheng |
| author_facet |
Tianzhi Huang Angel A. Alvarez Rajendra P. Pangeni Craig M. Horbinski Songjian Lu Sung-Hak Kim C. David James Jeffery J. Raizer John A. Kessler Cameron W. Brenann Erik P. Sulman Gaetano Finocchiaro Ming Tan Ryo Nishikawa Xinghua Lu Ichiro Nakano Bo Hu Shi-Yuan Cheng |
| author_sort |
Tianzhi Huang |
| title |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| title_short |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| title_full |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| title_fullStr |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| title_full_unstemmed |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways |
| title_sort |
regulatory circuit of mir-125b/mir-20b and wnt signalling controls glioblastoma phenotypes through fzd6-modulated pathways |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b31366b622e74db0ba44d725ba959681 |
| work_keys_str_mv |
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