Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.

Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence across racial/ethnic groups. Few studies have exam...

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Autores principales:	Deepak K Gupta, Geoffrey A Walford, Yong Ma, Petr Jarolim, Thomas J Wang, DPP Research Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b314d6c4dc52459493ba8670de66802a
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spelling	oai:doaj.org-article:b314d6c4dc52459493ba8670de66802a2021-12-02T20:05:47ZRacial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.1932-620310.1371/journal.pone.0229280https://doaj.org/article/b314d6c4dc52459493ba8670de66802a2020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0229280https://doaj.org/toc/1932-6203Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence across racial/ethnic groups. Few studies have examined whether circulating natriuretic peptide levels and their response to preventive interventions for DM2 differ by race/ethnicity. The Diabetes Prevention Program (DPP) is a clinical trial (July 31, 1996- July 31, 2001) that randomized participants to preventive interventions for DM2. Using stored serum samples, we examined N-terminus pro-B-type natriuretic peptide (NT-proBNP) levels in 3,220 individuals (56% white; 19% African-American; 15% Hispanic; 5% American-Indian; 5% Asian). The influence of race/ethnicity on NT-proBNP concentrations at baseline and after two years of treatment with placebo, lifestyle, or metformin was examined with multivariable-adjusted regression. At baseline, NT-proBNP differed significantly by race (P < .001), with the lowest values in African-American individuals. Hispanic individuals also had lower baseline NT-proBNP levels compared with whites (P< .001), while NT-proBNP levels were similar between white, American-Indian, and Asian individuals. At two years of follow-up, NT-proBNP levels decreased in African-Americans in each of the DPP study arms, whereas they were stable or increased in the other racial/ethnic groups. In the DPP, African-American individuals had lower circulating NT-proBNP levels compared with individuals in other racial/ethnic groups at baseline and after two years of preventive interventions. Further studies should examine the cardio-metabolic implications of lower natriuretic peptide levels in African-Americans. Trial Registration: ClinicalTrials.gov NCT00004992.Deepak K GuptaGeoffrey A WalfordYong MaPetr JarolimThomas J WangDPP Research GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 2, p e0229280 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deepak K Gupta Geoffrey A Walford Yong Ma Petr Jarolim Thomas J Wang DPP Research Group Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
description	Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence across racial/ethnic groups. Few studies have examined whether circulating natriuretic peptide levels and their response to preventive interventions for DM2 differ by race/ethnicity. The Diabetes Prevention Program (DPP) is a clinical trial (July 31, 1996- July 31, 2001) that randomized participants to preventive interventions for DM2. Using stored serum samples, we examined N-terminus pro-B-type natriuretic peptide (NT-proBNP) levels in 3,220 individuals (56% white; 19% African-American; 15% Hispanic; 5% American-Indian; 5% Asian). The influence of race/ethnicity on NT-proBNP concentrations at baseline and after two years of treatment with placebo, lifestyle, or metformin was examined with multivariable-adjusted regression. At baseline, NT-proBNP differed significantly by race (P < .001), with the lowest values in African-American individuals. Hispanic individuals also had lower baseline NT-proBNP levels compared with whites (P< .001), while NT-proBNP levels were similar between white, American-Indian, and Asian individuals. At two years of follow-up, NT-proBNP levels decreased in African-Americans in each of the DPP study arms, whereas they were stable or increased in the other racial/ethnic groups. In the DPP, African-American individuals had lower circulating NT-proBNP levels compared with individuals in other racial/ethnic groups at baseline and after two years of preventive interventions. Further studies should examine the cardio-metabolic implications of lower natriuretic peptide levels in African-Americans. Trial Registration: ClinicalTrials.gov NCT00004992.
format	article
author	Deepak K Gupta Geoffrey A Walford Yong Ma Petr Jarolim Thomas J Wang DPP Research Group
author_facet	Deepak K Gupta Geoffrey A Walford Yong Ma Petr Jarolim Thomas J Wang DPP Research Group
author_sort	Deepak K Gupta
title	Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
title_short	Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
title_full	Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
title_fullStr	Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
title_full_unstemmed	Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.
title_sort	racial/ethnic differences in circulating natriuretic peptide levels: the diabetes prevention program.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/b314d6c4dc52459493ba8670de66802a
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Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program.

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