Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic repo...

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Autores principales:	Wu Xiujuan, Zhao Zongfeng
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	nodular amyloidosis lymphatic malformation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b316062d2aec42479198f5ad5478339f
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spelling	oai:doaj.org-article:b316062d2aec42479198f5ad5478339f2021-12-05T14:10:41ZPrimary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report2391-541210.1515/biol-2021-0076https://doaj.org/article/b316062d2aec42479198f5ad5478339f2021-08-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0076https://doaj.org/toc/2391-5412Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.Wu XiujuanZhao ZongfengDe Gruyterarticlenodular amyloidosislymphatic malformationBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 781-784 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nodular amyloidosis lymphatic malformation Biology (General) QH301-705.5
spellingShingle	nodular amyloidosis lymphatic malformation Biology (General) QH301-705.5 Wu Xiujuan Zhao Zongfeng Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
description	Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.
format	article
author	Wu Xiujuan Zhao Zongfeng
author_facet	Wu Xiujuan Zhao Zongfeng
author_sort	Wu Xiujuan
title	Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
title_short	Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
title_full	Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
title_fullStr	Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
title_full_unstemmed	Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
title_sort	primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: a case report
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/b316062d2aec42479198f5ad5478339f
work_keys_str_mv	AT wuxiujuan primarylocalizedcutaneousnodularamyloidosispresentingaslymphaticmalformationacasereport AT zhaozongfeng primarylocalizedcutaneousnodularamyloidosispresentingaslymphaticmalformationacasereport
_version_	1718371860170670080

Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

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