Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay

Abstract Phosphorylation of the histone protein H2AX to form γ-H2AX foci directly represents DNA double-strand break formation. Traditional γ-H2AX detection involves counting individual foci within individual nuclei. The novelty of this work is the application of a time-resolved fluorescence assay u...

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Autores principales: Felicite K. Noubissi, Amber A. McBride, Hannah G. Leppert, Larry J. Millet, Xiaofei Wang, Sandra M. Davern
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b318484cefd641de873ac56966a7f9c7
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