NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 act...

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Autores principales:	Priscila Rezeck Nunes, Sarah Viana Mattioli, Valeria Cristina Sandrim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NLRP3 preeclampsia nitric oxide endothelial dysfunction oxidative stress inflammation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b3196ddd8e02457f838ceebfdc3d444e
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spelling	oai:doaj.org-article:b3196ddd8e02457f838ceebfdc3d444e2021-11-25T17:07:41ZNLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions10.3390/cells101128282073-4409https://doaj.org/article/b3196ddd8e02457f838ceebfdc3d444e2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2828https://doaj.org/toc/2073-4409Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Furthermore, reactive oxygen species (ROS), act as an intermediate to activate NLRP3, contributing to subsequent inflammatory cascades and cell damage. Moreover, increased production of ROS may elevate nitric oxide (NO) catabolism and consequently decrease NO bioavailability. NO has many roles in immune responses, including the regulation of signaling cascades. At the site of inflammation, vascular endothelium is crucial in the regulation of systemic inflammation with important implications for homeostasis. In this review, we present the important role of NLRP3 activation in exacerbating oxidative stress and endothelial dysfunction. Considering that the causes related to these processes and inflammation in PE remain a challenge for clinical practice, the use of drugs related to inhibition of the NLRP3 may be a good option for future solutions for this disease.Priscila Rezeck NunesSarah Viana MattioliValeria Cristina SandrimMDPI AGarticleNLRP3preeclampsianitric oxideendothelial dysfunctionoxidative stressinflammationBiology (General)QH301-705.5ENCells, Vol 10, Iss 2828, p 2828 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NLRP3 preeclampsia nitric oxide endothelial dysfunction oxidative stress inflammation Biology (General) QH301-705.5
spellingShingle	NLRP3 preeclampsia nitric oxide endothelial dysfunction oxidative stress inflammation Biology (General) QH301-705.5 Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
description	Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Furthermore, reactive oxygen species (ROS), act as an intermediate to activate NLRP3, contributing to subsequent inflammatory cascades and cell damage. Moreover, increased production of ROS may elevate nitric oxide (NO) catabolism and consequently decrease NO bioavailability. NO has many roles in immune responses, including the regulation of signaling cascades. At the site of inflammation, vascular endothelium is crucial in the regulation of systemic inflammation with important implications for homeostasis. In this review, we present the important role of NLRP3 activation in exacerbating oxidative stress and endothelial dysfunction. Considering that the causes related to these processes and inflammation in PE remain a challenge for clinical practice, the use of drugs related to inhibition of the NLRP3 may be a good option for future solutions for this disease.
format	article
author	Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim
author_facet	Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim
author_sort	Priscila Rezeck Nunes
title	NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
title_short	NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
title_full	NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
title_fullStr	NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
title_full_unstemmed	NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
title_sort	nlrp3 activation and its relationship to endothelial dysfunction and oxidative stress: implications for preeclampsia and pharmacological interventions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3196ddd8e02457f838ceebfdc3d444e
work_keys_str_mv	AT priscilarezecknunes nlrp3activationanditsrelationshiptoendothelialdysfunctionandoxidativestressimplicationsforpreeclampsiaandpharmacologicalinterventions AT sarahvianamattioli nlrp3activationanditsrelationshiptoendothelialdysfunctionandoxidativestressimplicationsforpreeclampsiaandpharmacologicalinterventions AT valeriacristinasandrim nlrp3activationanditsrelationshiptoendothelialdysfunctionandoxidativestressimplicationsforpreeclampsiaandpharmacologicalinterventions
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NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

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