An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling

Humans require about 20 chemical elements. Half of them are essential metal ions. Many additional, non-essential metal ions are present in our bodies through environmental exposures, including in our diet, with functional consequences. Their accumulation is accelerated due to the increasing pollutio...

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Autor principal:	Wolfgang Maret
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metallomics metal ion signaling chemical elements bioinorganic chemistry homeostatic control health outcomes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b3197debdf2d45edbdc03f7bbca32105
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spelling	oai:doaj.org-article:b3197debdf2d45edbdc03f7bbca321052021-11-25T16:39:16ZAn Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling10.3390/app1122108462076-3417https://doaj.org/article/b3197debdf2d45edbdc03f7bbca321052021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10846https://doaj.org/toc/2076-3417Humans require about 20 chemical elements. Half of them are essential metal ions. Many additional, non-essential metal ions are present in our bodies through environmental exposures, including in our diet, with functional consequences. Their accumulation is accelerated due to the increasing pollution of soil, air, water and manufacturing processes that employ chemical elements to which we have not been exposed in our evolutionary history. Yet other metal ions are essential for other forms of life, which calls on life scientists to consider the interactions of life processes with most of the chemical elements in the periodic table. Only in this century have attempts been made to integrate specialty disciplines into a science of bioelements called metallomics. Metallomics forms a fifth group when added to the traditional four building blocks of living cells and their areas of investigations, i.e., sugars (glycomics), fats (lipidomics), proteins (proteomics) and nucleic acids (genomics). Neither an understanding of all the essential metals and their interactions nor the functional impacts of the non-essential metals for life, except established toxic elements such as lead, are widely perceived as important in the basic science communities and in the applied sciences such as medicine and engineering. It is a remarkable oversight that this article attempts to address with representative examples.Wolfgang MaretMDPI AGarticlemetallomicsmetal ion signalingchemical elementsbioinorganic chemistryhomeostatic controlhealth outcomesTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10846, p 10846 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metallomics metal ion signaling chemical elements bioinorganic chemistry homeostatic control health outcomes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	metallomics metal ion signaling chemical elements bioinorganic chemistry homeostatic control health outcomes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Wolfgang Maret An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
description	Humans require about 20 chemical elements. Half of them are essential metal ions. Many additional, non-essential metal ions are present in our bodies through environmental exposures, including in our diet, with functional consequences. Their accumulation is accelerated due to the increasing pollution of soil, air, water and manufacturing processes that employ chemical elements to which we have not been exposed in our evolutionary history. Yet other metal ions are essential for other forms of life, which calls on life scientists to consider the interactions of life processes with most of the chemical elements in the periodic table. Only in this century have attempts been made to integrate specialty disciplines into a science of bioelements called metallomics. Metallomics forms a fifth group when added to the traditional four building blocks of living cells and their areas of investigations, i.e., sugars (glycomics), fats (lipidomics), proteins (proteomics) and nucleic acids (genomics). Neither an understanding of all the essential metals and their interactions nor the functional impacts of the non-essential metals for life, except established toxic elements such as lead, are widely perceived as important in the basic science communities and in the applied sciences such as medicine and engineering. It is a remarkable oversight that this article attempts to address with representative examples.
format	article
author	Wolfgang Maret
author_facet	Wolfgang Maret
author_sort	Wolfgang Maret
title	An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
title_short	An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
title_full	An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
title_fullStr	An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
title_full_unstemmed	An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling
title_sort	appraisal of the field of metallomics and the roles of metal ions in biochemistry and cell signaling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3197debdf2d45edbdc03f7bbca32105
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An Appraisal of the Field of Metallomics and the Roles of Metal Ions in Biochemistry and Cell Signaling

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