COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry
Background: Cancer patients are at higher risk of COVID-19 complications and mortality than the rest of the population. Breast cancer patients seem to have better prognosis when infected by SARS-CoV-2 than other cancer patients. Methods: We report a subanalysis of the OnCovid study providing more de...
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SAGE Publishing
2021
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oai:doaj.org-article:b31f994a0fcd4f9381a3a63cd473505b2021-11-03T22:04:01ZCOVID-19 in breast cancer patients: a subanalysis of the OnCovid registry1758-835910.1177/17588359211053416https://doaj.org/article/b31f994a0fcd4f9381a3a63cd473505b2021-11-01T00:00:00Zhttps://doi.org/10.1177/17588359211053416https://doaj.org/toc/1758-8359Background: Cancer patients are at higher risk of COVID-19 complications and mortality than the rest of the population. Breast cancer patients seem to have better prognosis when infected by SARS-CoV-2 than other cancer patients. Methods: We report a subanalysis of the OnCovid study providing more detailed information in the breast cancer population. Results: We included 495 breast cancer patients with a SARS-CoV-2 infection. Mean age was 62.6 years; 31.5% presented more than one comorbidity. The most frequent breast cancer subtype was luminal-like ( n = 245, 49.5%) and 177 (35.8%) had metastatic disease. A total of 332 (67.1%) patients were receiving active treatment, with radical intent in 232 (47.6%) of them. Hospitalization rate was 58.2% and all-cause mortality rate was 20.3%. One hundred twenty-nine (26.1%) patients developed one COVID-19 complication, being acute respiratory failure the most common ( n = 74, 15.0%). In the multivariable analysis, age older than 70 years, presence of COVID-19 complications, and metastatic disease were factors correlated with worse outcomes, while ongoing anticancer therapy at time of COVID-19 diagnosis appeared to be a protective factor. No particular oncological treatment was related to higher risk of complications. In the context of SARS-CoV-2 infection, 73 (18.3%) patients had some kind of modification on their oncologic treatment. At the first oncological reassessment (median time: 46.9 days ± 36.7), 255 (51.6%) patients reported to be fully recovered from the infection. There were 39 patients (7.9%) with long-term SARS-CoV-2-related complications. Conclusion: In the context of COVID-19, our data confirm that breast cancer patients appear to have lower complications and mortality rate than expected in other cancer populations. Most breast cancer patients can be safely treated for their neoplasm during SARS-CoV-2 pandemic. Oncological treatment has no impact on the risk of SARS-CoV-2 complications, and, especially in the curative setting, the treatment should be modified as little as possible.Laia GarrigósCristina SauraClara Martinez-VilaAlberto ZambelliMark BowerBarbara PistilliMatteo LambertiniDiego OttavianiNikolaos DiamantisAilsa LumsdenSonia PernasDaniele GeneraliElia SeguíGemma ViñasEudald FelipAna SanchezGianpiero RizzoArmando SantoroAlessio CortelliniYlenia PeroneJohn ChesterMaria IglesiasMarta BettiBruno VincenziMichela LibertiniFrancesca MazzoniFederica ZorattoRossana BerardiAnnalisa GuidaRachel WuerstleinAngela LoizidouRachel SharkeyJuan Aguilar CompanyMarta MatasChiara SaggiaLorenzo ChiudinelliEmeline Colomba-BlamebleMyria GalaziUma MukherjeeMieke Van HemelrijckMar MarinCarla StrinaAleix PratHelena PlaEva Maria CiruelosAlexia BertuzziLucia del MastroGiampiero PorzioThomas Newsom-DavisIsabel RuizMaria Belen DelanyMarco KrengliVittoria FotiaAlessandro ViansoneNeha ChopraMargarita RomeoRamon SalazarIgnacio PerezFrancesca d’AvanzoMichela FranchiManuela MilaniFanny PommeretMarco TucciPaolo PedrazzoliNadia HarbeckDaniela FerranteDavid J. PinatoAlessandra GennariSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTherapeutic Advances in Medical Oncology, Vol 13 (2021) |
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DOAJ |
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EN |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Laia Garrigós Cristina Saura Clara Martinez-Vila Alberto Zambelli Mark Bower Barbara Pistilli Matteo Lambertini Diego Ottaviani Nikolaos Diamantis Ailsa Lumsden Sonia Pernas Daniele Generali Elia Seguí Gemma Viñas Eudald Felip Ana Sanchez Gianpiero Rizzo Armando Santoro Alessio Cortellini Ylenia Perone John Chester Maria Iglesias Marta Betti Bruno Vincenzi Michela Libertini Francesca Mazzoni Federica Zoratto Rossana Berardi Annalisa Guida Rachel Wuerstlein Angela Loizidou Rachel Sharkey Juan Aguilar Company Marta Matas Chiara Saggia Lorenzo Chiudinelli Emeline Colomba-Blameble Myria Galazi Uma Mukherjee Mieke Van Hemelrijck Mar Marin Carla Strina Aleix Prat Helena Pla Eva Maria Ciruelos Alexia Bertuzzi Lucia del Mastro Giampiero Porzio Thomas Newsom-Davis Isabel Ruiz Maria Belen Delany Marco Krengli Vittoria Fotia Alessandro Viansone Neha Chopra Margarita Romeo Ramon Salazar Ignacio Perez Francesca d’Avanzo Michela Franchi Manuela Milani Fanny Pommeret Marco Tucci Paolo Pedrazzoli Nadia Harbeck Daniela Ferrante David J. Pinato Alessandra Gennari COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| description |
Background: Cancer patients are at higher risk of COVID-19 complications and mortality than the rest of the population. Breast cancer patients seem to have better prognosis when infected by SARS-CoV-2 than other cancer patients. Methods: We report a subanalysis of the OnCovid study providing more detailed information in the breast cancer population. Results: We included 495 breast cancer patients with a SARS-CoV-2 infection. Mean age was 62.6 years; 31.5% presented more than one comorbidity. The most frequent breast cancer subtype was luminal-like ( n = 245, 49.5%) and 177 (35.8%) had metastatic disease. A total of 332 (67.1%) patients were receiving active treatment, with radical intent in 232 (47.6%) of them. Hospitalization rate was 58.2% and all-cause mortality rate was 20.3%. One hundred twenty-nine (26.1%) patients developed one COVID-19 complication, being acute respiratory failure the most common ( n = 74, 15.0%). In the multivariable analysis, age older than 70 years, presence of COVID-19 complications, and metastatic disease were factors correlated with worse outcomes, while ongoing anticancer therapy at time of COVID-19 diagnosis appeared to be a protective factor. No particular oncological treatment was related to higher risk of complications. In the context of SARS-CoV-2 infection, 73 (18.3%) patients had some kind of modification on their oncologic treatment. At the first oncological reassessment (median time: 46.9 days ± 36.7), 255 (51.6%) patients reported to be fully recovered from the infection. There were 39 patients (7.9%) with long-term SARS-CoV-2-related complications. Conclusion: In the context of COVID-19, our data confirm that breast cancer patients appear to have lower complications and mortality rate than expected in other cancer populations. Most breast cancer patients can be safely treated for their neoplasm during SARS-CoV-2 pandemic. Oncological treatment has no impact on the risk of SARS-CoV-2 complications, and, especially in the curative setting, the treatment should be modified as little as possible. |
| format |
article |
| author |
Laia Garrigós Cristina Saura Clara Martinez-Vila Alberto Zambelli Mark Bower Barbara Pistilli Matteo Lambertini Diego Ottaviani Nikolaos Diamantis Ailsa Lumsden Sonia Pernas Daniele Generali Elia Seguí Gemma Viñas Eudald Felip Ana Sanchez Gianpiero Rizzo Armando Santoro Alessio Cortellini Ylenia Perone John Chester Maria Iglesias Marta Betti Bruno Vincenzi Michela Libertini Francesca Mazzoni Federica Zoratto Rossana Berardi Annalisa Guida Rachel Wuerstlein Angela Loizidou Rachel Sharkey Juan Aguilar Company Marta Matas Chiara Saggia Lorenzo Chiudinelli Emeline Colomba-Blameble Myria Galazi Uma Mukherjee Mieke Van Hemelrijck Mar Marin Carla Strina Aleix Prat Helena Pla Eva Maria Ciruelos Alexia Bertuzzi Lucia del Mastro Giampiero Porzio Thomas Newsom-Davis Isabel Ruiz Maria Belen Delany Marco Krengli Vittoria Fotia Alessandro Viansone Neha Chopra Margarita Romeo Ramon Salazar Ignacio Perez Francesca d’Avanzo Michela Franchi Manuela Milani Fanny Pommeret Marco Tucci Paolo Pedrazzoli Nadia Harbeck Daniela Ferrante David J. Pinato Alessandra Gennari |
| author_facet |
Laia Garrigós Cristina Saura Clara Martinez-Vila Alberto Zambelli Mark Bower Barbara Pistilli Matteo Lambertini Diego Ottaviani Nikolaos Diamantis Ailsa Lumsden Sonia Pernas Daniele Generali Elia Seguí Gemma Viñas Eudald Felip Ana Sanchez Gianpiero Rizzo Armando Santoro Alessio Cortellini Ylenia Perone John Chester Maria Iglesias Marta Betti Bruno Vincenzi Michela Libertini Francesca Mazzoni Federica Zoratto Rossana Berardi Annalisa Guida Rachel Wuerstlein Angela Loizidou Rachel Sharkey Juan Aguilar Company Marta Matas Chiara Saggia Lorenzo Chiudinelli Emeline Colomba-Blameble Myria Galazi Uma Mukherjee Mieke Van Hemelrijck Mar Marin Carla Strina Aleix Prat Helena Pla Eva Maria Ciruelos Alexia Bertuzzi Lucia del Mastro Giampiero Porzio Thomas Newsom-Davis Isabel Ruiz Maria Belen Delany Marco Krengli Vittoria Fotia Alessandro Viansone Neha Chopra Margarita Romeo Ramon Salazar Ignacio Perez Francesca d’Avanzo Michela Franchi Manuela Milani Fanny Pommeret Marco Tucci Paolo Pedrazzoli Nadia Harbeck Daniela Ferrante David J. Pinato Alessandra Gennari |
| author_sort |
Laia Garrigós |
| title |
COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| title_short |
COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| title_full |
COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| title_fullStr |
COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| title_full_unstemmed |
COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry |
| title_sort |
covid-19 in breast cancer patients: a subanalysis of the oncovid registry |
| publisher |
SAGE Publishing |
| publishDate |
2021 |
| url |
https://doaj.org/article/b31f994a0fcd4f9381a3a63cd473505b |
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