Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model

Abstract Liver fibrosis plays a crucial role in promoting tumor immune escape and tumor aggressiveness for liver cancer. However, an interesting phenomenon is that the tumor size of liver cancer patients with liver fibrosis is smaller than that of patients without liver fibrosis. In this study, 16 S...

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Autores principales:	Tongqiang Li, Jiacheng Liu, Yingliang Wang, Chen Zhou, Qin Shi, Songjiang Huang, Chongtu Yang, Yang Chen, Yaowei Bai, Bin Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b322eda3e39a448895d0f090ea6af237
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spelling	oai:doaj.org-article:b322eda3e39a448895d0f090ea6af2372021-11-28T12:19:15ZLiver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model10.1038/s41598-021-02155-92045-2322https://doaj.org/article/b322eda3e39a448895d0f090ea6af2372021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02155-9https://doaj.org/toc/2045-2322Abstract Liver fibrosis plays a crucial role in promoting tumor immune escape and tumor aggressiveness for liver cancer. However, an interesting phenomenon is that the tumor size of liver cancer patients with liver fibrosis is smaller than that of patients without liver fibrosis. In this study, 16 SD rats were used to establish orthotopic liver tumor transplantation models with Walker-256 cell lines, respectively on the fibrotic liver (n = 8, LF group) and normal liver (n = 8, control group). MRI (magnetic resonance imaging) was used to monitor the size of the tumors. All rats were executed at the third week after modeling, and the immunohistochemical staining was used to reflect the changes in the tumor microenvironment. The results showed that, compared to the control group, the PD-L1 (programmed cell death protein receptor-L1) expression was higher, and the neutrophil infiltration increased while the effector (CD8+) T cell infiltration decreased in the LF group. Additionally, the expression of MMP-9 (matrix metalloproteinase-9) of tumor tissue in the LF group increased. Three weeks after modeling, the size of tumors in the LF group was significantly smaller than that in the control group (382.47 ± 195.06 mm3 vs. 1736.21 ± 657.25 mm3, P < 0.001). Taken together, we concluded that liver fibrosis facilitated tumor immunity escape but limited the expansion of tumor size.Tongqiang LiJiacheng LiuYingliang WangChen ZhouQin ShiSongjiang HuangChongtu YangYang ChenYaowei BaiBin XiongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongqiang Li Jiacheng Liu Yingliang Wang Chen Zhou Qin Shi Songjiang Huang Chongtu Yang Yang Chen Yaowei Bai Bin Xiong Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
description	Abstract Liver fibrosis plays a crucial role in promoting tumor immune escape and tumor aggressiveness for liver cancer. However, an interesting phenomenon is that the tumor size of liver cancer patients with liver fibrosis is smaller than that of patients without liver fibrosis. In this study, 16 SD rats were used to establish orthotopic liver tumor transplantation models with Walker-256 cell lines, respectively on the fibrotic liver (n = 8, LF group) and normal liver (n = 8, control group). MRI (magnetic resonance imaging) was used to monitor the size of the tumors. All rats were executed at the third week after modeling, and the immunohistochemical staining was used to reflect the changes in the tumor microenvironment. The results showed that, compared to the control group, the PD-L1 (programmed cell death protein receptor-L1) expression was higher, and the neutrophil infiltration increased while the effector (CD8+) T cell infiltration decreased in the LF group. Additionally, the expression of MMP-9 (matrix metalloproteinase-9) of tumor tissue in the LF group increased. Three weeks after modeling, the size of tumors in the LF group was significantly smaller than that in the control group (382.47 ± 195.06 mm3 vs. 1736.21 ± 657.25 mm3, P < 0.001). Taken together, we concluded that liver fibrosis facilitated tumor immunity escape but limited the expansion of tumor size.
format	article
author	Tongqiang Li Jiacheng Liu Yingliang Wang Chen Zhou Qin Shi Songjiang Huang Chongtu Yang Yang Chen Yaowei Bai Bin Xiong
author_facet	Tongqiang Li Jiacheng Liu Yingliang Wang Chen Zhou Qin Shi Songjiang Huang Chongtu Yang Yang Chen Yaowei Bai Bin Xiong
author_sort	Tongqiang Li
title	Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
title_short	Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
title_full	Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
title_fullStr	Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
title_full_unstemmed	Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
title_sort	liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b322eda3e39a448895d0f090ea6af237
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Liver fibrosis promotes immunity escape but limits the size of liver tumor in a rat orthotopic transplantation model

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