How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients

Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have...

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Autores principales:	Carlos Vazquez-Sosa, Stacey D Clegg, James C Blankenship
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b323103fa1b54065adbaba5e98ebeea0
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spelling	oai:doaj.org-article:b323103fa1b54065adbaba5e98ebeea02021-12-04T16:05:08ZHow Old is Too Old? Closure of Patent Foramen Ovale in Older Patients10.15420/usc.2020.401758-390X1758-3896https://doaj.org/article/b323103fa1b54065adbaba5e98ebeea02021-10-01T00:00:00Zhttps://www.uscjournal.com/articleindex/usc.2020.40https://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XPercutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have other cardiac and vascular conditions that are common risk factors for stroke, whereas paradoxical embolism through a PFO is relatively rare. Younger patients theoretically benefit the most from closure due to longer lifetime exposure risk and absence of other traditional risk factors. PFO in older patients with cryptogenic strokes is often encountered in clinical practice, making up an increasing number of cardiology referrals, yet cardiologists lack guidelines and evaluation tools for these patients. This review explores the history of PFO closure – emphasizing data in older adults – and discusses the evaluation and treatment of older people with cryptogenic stroke and PFO while further trials in this important population are awaited.Carlos Vazquez-SosaStacey D CleggJames C BlankenshipRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 15, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
description	Percutaneous closure of a patent foramen ovale (PFO) reduces the risk of recurrent cryptogenic stroke specifically in younger patients. The three randomized controlled trials that led to the widespread adoption of PFO closure excluded patients over the age of 60 years. Older patients frequently have other cardiac and vascular conditions that are common risk factors for stroke, whereas paradoxical embolism through a PFO is relatively rare. Younger patients theoretically benefit the most from closure due to longer lifetime exposure risk and absence of other traditional risk factors. PFO in older patients with cryptogenic strokes is often encountered in clinical practice, making up an increasing number of cardiology referrals, yet cardiologists lack guidelines and evaluation tools for these patients. This review explores the history of PFO closure – emphasizing data in older adults – and discusses the evaluation and treatment of older people with cryptogenic stroke and PFO while further trials in this important population are awaited.
format	article
author	Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship
author_facet	Carlos Vazquez-Sosa Stacey D Clegg James C Blankenship
author_sort	Carlos Vazquez-Sosa
title	How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
title_short	How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
title_full	How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
title_fullStr	How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
title_full_unstemmed	How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients
title_sort	how old is too old? closure of patent foramen ovale in older patients
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/b323103fa1b54065adbaba5e98ebeea0
work_keys_str_mv	AT carlosvazquezsosa howoldistoooldclosureofpatentforamenovaleinolderpatients AT staceydclegg howoldistoooldclosureofpatentforamenovaleinolderpatients AT jamescblankenship howoldistoooldclosureofpatentforamenovaleinolderpatients
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How Old is Too Old? Closure of Patent Foramen Ovale in Older Patients

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