Aβ-induced vulnerability propagates via the brain’s default mode network

Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally con...

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Autores principales:	Tharick A. Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Sara Mohaddes, Monica Shin, Ah Yeon Park, Maxime J. Parent, Andrea L. Benedet, Mira Chamoun, Joseph Therriault, Heungsun Hwang, A. Claudio Cuello, Bratislav Misic, Jean-Paul Soucy, John A. D. Aston, Serge Gauthier, Pedro Rosa-Neto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3232c605c38460fa526e6a7ba30b7cd
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spelling	oai:doaj.org-article:b3232c605c38460fa526e6a7ba30b7cd2021-12-02T16:57:45ZAβ-induced vulnerability propagates via the brain’s default mode network10.1038/s41467-019-10217-w2041-1723https://doaj.org/article/b3232c605c38460fa526e6a7ba30b7cd2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10217-whttps://doaj.org/toc/2041-1723Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally connected areas.Tharick A. PascoalSulantha MathotaarachchiMin Su KangSara MohaddesMonica ShinAh Yeon ParkMaxime J. ParentAndrea L. BenedetMira ChamounJoseph TherriaultHeungsun HwangA. Claudio CuelloBratislav MisicJean-Paul SoucyJohn A. D. AstonSerge GauthierPedro Rosa-NetoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tharick A. Pascoal Sulantha Mathotaarachchi Min Su Kang Sara Mohaddes Monica Shin Ah Yeon Park Maxime J. Parent Andrea L. Benedet Mira Chamoun Joseph Therriault Heungsun Hwang A. Claudio Cuello Bratislav Misic Jean-Paul Soucy John A. D. Aston Serge Gauthier Pedro Rosa-Neto Aβ-induced vulnerability propagates via the brain’s default mode network
description	Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally connected areas.
format	article
author	Tharick A. Pascoal Sulantha Mathotaarachchi Min Su Kang Sara Mohaddes Monica Shin Ah Yeon Park Maxime J. Parent Andrea L. Benedet Mira Chamoun Joseph Therriault Heungsun Hwang A. Claudio Cuello Bratislav Misic Jean-Paul Soucy John A. D. Aston Serge Gauthier Pedro Rosa-Neto
author_facet	Tharick A. Pascoal Sulantha Mathotaarachchi Min Su Kang Sara Mohaddes Monica Shin Ah Yeon Park Maxime J. Parent Andrea L. Benedet Mira Chamoun Joseph Therriault Heungsun Hwang A. Claudio Cuello Bratislav Misic Jean-Paul Soucy John A. D. Aston Serge Gauthier Pedro Rosa-Neto
author_sort	Tharick A. Pascoal
title	Aβ-induced vulnerability propagates via the brain’s default mode network
title_short	Aβ-induced vulnerability propagates via the brain’s default mode network
title_full	Aβ-induced vulnerability propagates via the brain’s default mode network
title_fullStr	Aβ-induced vulnerability propagates via the brain’s default mode network
title_full_unstemmed	Aβ-induced vulnerability propagates via the brain’s default mode network
title_sort	aβ-induced vulnerability propagates via the brain’s default mode network
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b3232c605c38460fa526e6a7ba30b7cd
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Aβ-induced vulnerability propagates via the brain’s default mode network

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