Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis

This study is aimed at determining the association of inflammatory markers and proinflammatory cytokines with cardiovascular risk manifestation in women with endometriosis as compared to healthy controls. A total of 181 females of reproductive age with the absence of other inflammatory or autoimmune...

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Autores principales:	Uzma Rafi, Shaaf Ahmad, Syeda Shazia Bokhari, Muhammad Amir Iqbal, Amna Zia, Muhammad Amjad Khan, Nabila Roohi
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/b328aad1dccf441492b4a86155c3bf99
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spelling	oai:doaj.org-article:b328aad1dccf441492b4a86155c3bf992021-11-08T02:36:57ZAssociation of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis1466-186110.1155/2021/3425560https://doaj.org/article/b328aad1dccf441492b4a86155c3bf992021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3425560https://doaj.org/toc/1466-1861This study is aimed at determining the association of inflammatory markers and proinflammatory cytokines with cardiovascular risk manifestation in women with endometriosis as compared to healthy controls. A total of 181 females of reproductive age with the absence of other inflammatory or autoimmune disorders and a lack of hormonal therapy for at least 6 months voluntarily participated in this investigation. Patients were 81 females, laparoscopically diagnosed with endometriosis, while the control group comprised 80 healthy females without any pelvic pathology. All subjects were 20-40 years of age. Exclusion criteria were diabetes, obesity, hypertension, metabolic diseases, cardiovascular, and renal disorders. C-reactive protein, fibrinogen, homocysteine, interleukin-17, and interleukin-33 were analyzed using commercially available ELISA kits. For statistical interpretation, the unpaired Student “t” test was used. All inflammatory markers and cytokines demonstrated elevated levels (P<0.001) in endometriosis patients as compared to healthy controls. The results of the study revealed that the patients with endometriosis demonstrate a hypercoagulable status due to inflammation, which initiates atherosclerosis and associated complications. Hence, endometriosis can cause a risk of cardiovascular disorders in these patients.Uzma RafiShaaf AhmadSyeda Shazia BokhariMuhammad Amir IqbalAmna ZiaMuhammad Amjad KhanNabila RoohiHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Uzma Rafi Shaaf Ahmad Syeda Shazia Bokhari Muhammad Amir Iqbal Amna Zia Muhammad Amjad Khan Nabila Roohi Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
description	This study is aimed at determining the association of inflammatory markers and proinflammatory cytokines with cardiovascular risk manifestation in women with endometriosis as compared to healthy controls. A total of 181 females of reproductive age with the absence of other inflammatory or autoimmune disorders and a lack of hormonal therapy for at least 6 months voluntarily participated in this investigation. Patients were 81 females, laparoscopically diagnosed with endometriosis, while the control group comprised 80 healthy females without any pelvic pathology. All subjects were 20-40 years of age. Exclusion criteria were diabetes, obesity, hypertension, metabolic diseases, cardiovascular, and renal disorders. C-reactive protein, fibrinogen, homocysteine, interleukin-17, and interleukin-33 were analyzed using commercially available ELISA kits. For statistical interpretation, the unpaired Student “t” test was used. All inflammatory markers and cytokines demonstrated elevated levels (P<0.001) in endometriosis patients as compared to healthy controls. The results of the study revealed that the patients with endometriosis demonstrate a hypercoagulable status due to inflammation, which initiates atherosclerosis and associated complications. Hence, endometriosis can cause a risk of cardiovascular disorders in these patients.
format	article
author	Uzma Rafi Shaaf Ahmad Syeda Shazia Bokhari Muhammad Amir Iqbal Amna Zia Muhammad Amjad Khan Nabila Roohi
author_facet	Uzma Rafi Shaaf Ahmad Syeda Shazia Bokhari Muhammad Amir Iqbal Amna Zia Muhammad Amjad Khan Nabila Roohi
author_sort	Uzma Rafi
title	Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
title_short	Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
title_full	Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
title_fullStr	Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
title_full_unstemmed	Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis
title_sort	association of inflammatory markers/cytokines with cardiovascular risk manifestation in patients with endometriosis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/b328aad1dccf441492b4a86155c3bf99
work_keys_str_mv	AT uzmarafi associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT shaafahmad associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT syedashaziabokhari associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT muhammadamiriqbal associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT amnazia associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT muhammadamjadkhan associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis AT nabilaroohi associationofinflammatorymarkerscytokineswithcardiovascularriskmanifestationinpatientswithendometriosis
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Association of Inflammatory Markers/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis

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