Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration.

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration.

Polysialic acid (polySia), an α-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated post-translational modification predominantly found on NCAM (neuronal cell adhesion molecule). Whilst high levels are expressed during development, peripheral adult organs do not express...

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Autores principales: Yousef M J Al-Saraireh, Mark Sutherland, Bradley R Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M Loadman, Rachel J Errington, Paul J Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H Patterson, Steven D Shnyder, Robert A Falconer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/b3297dba32f944dfb85067dbb3133a97
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