Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress

Auditory system senescence: Mitochondrial dynamics and respiration The mitochondrial morphology and physiology could influence the process of age-related hearing loss. Prof. Tatsuya Yamasoba’s research group at the University of Tokyo has examined the functional changes of mitochondria in terms of i...

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Autores principales:	Teru Kamogashira, Ken Hayashi, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b32cd4c02d5741e68cba2a19dba4174f
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spelling	oai:doaj.org-article:b32cd4c02d5741e68cba2a19dba4174f2021-12-02T16:05:42ZFunctionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress10.1038/s41514-017-0002-22056-3973https://doaj.org/article/b32cd4c02d5741e68cba2a19dba4174f2017-01-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0002-2https://doaj.org/toc/2056-3973Auditory system senescence: Mitochondrial dynamics and respiration The mitochondrial morphology and physiology could influence the process of age-related hearing loss. Prof. Tatsuya Yamasoba’s research group at the University of Tokyo has examined the functional changes of mitochondria in terms of its respiratory function, membrane potential and morphology under premature senescence induced by oxidative stress in an auditory cell line. The morphological and functional mitochondrial damage were observed as the respiratory capacity deficiency and the fluctuation of the fusion/fission balance. Their results provide evidence of the fundamental interdependence between mitochondrial metabolic activity and its network structure in premature senescence process of auditory cells. This is a pioneer study to indicate the influence of mitochondrial dynamics and respiratory system on the premature senescence process of auditory cells. Further studies into inter cellular communication including cytoskeleton and nucleus can help us understand the etiology underlying age-related hearing loss.Teru KamogashiraKen HayashiChisato FujimotoShinichi IwasakiTatsuya YamasobaNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Teru Kamogashira Ken Hayashi Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
description	Auditory system senescence: Mitochondrial dynamics and respiration The mitochondrial morphology and physiology could influence the process of age-related hearing loss. Prof. Tatsuya Yamasoba’s research group at the University of Tokyo has examined the functional changes of mitochondria in terms of its respiratory function, membrane potential and morphology under premature senescence induced by oxidative stress in an auditory cell line. The morphological and functional mitochondrial damage were observed as the respiratory capacity deficiency and the fluctuation of the fusion/fission balance. Their results provide evidence of the fundamental interdependence between mitochondrial metabolic activity and its network structure in premature senescence process of auditory cells. This is a pioneer study to indicate the influence of mitochondrial dynamics and respiratory system on the premature senescence process of auditory cells. Further studies into inter cellular communication including cytoskeleton and nucleus can help us understand the etiology underlying age-related hearing loss.
format	article
author	Teru Kamogashira Ken Hayashi Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba
author_facet	Teru Kamogashira Ken Hayashi Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba
author_sort	Teru Kamogashira
title	Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
title_short	Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
title_full	Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
title_fullStr	Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
title_full_unstemmed	Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
title_sort	functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b32cd4c02d5741e68cba2a19dba4174f
work_keys_str_mv	AT terukamogashira functionallyandmorphologicallydamagedmitochondriaobservedinauditorycellsundersenescenceinducingstress AT kenhayashi functionallyandmorphologicallydamagedmitochondriaobservedinauditorycellsundersenescenceinducingstress AT chisatofujimoto functionallyandmorphologicallydamagedmitochondriaobservedinauditorycellsundersenescenceinducingstress AT shinichiiwasaki functionallyandmorphologicallydamagedmitochondriaobservedinauditorycellsundersenescenceinducingstress AT tatsuyayamasoba functionallyandmorphologicallydamagedmitochondriaobservedinauditorycellsundersenescenceinducingstress
_version_	1718385170120179712

Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress

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