Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization
Histones have a role in antimicrobial defense. Here, the authors show that the histone H2A and the antimicrobial peptide LL-37 exert synergistic effects by enhancing bacterial membrane pores and enabling H2A entry into the bacterial cytoplasm, where it reorganizes DNA and inhibits transcription.
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
|
| Subjects: | |
| Online Access: | https://doaj.org/article/b32d941bdfe447b68dbe6452c3da533c |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!