Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal in...

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Autores principales:	Jingyu Li, Wenli Shi, Hanxiao Sun, Yan Ji, Yuqin Chen, Xiaohuan Guo, Huiming Sheng, Jie Shu, Liang Zhou, Ting Cai, Ju Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b32e5963fa904384baa13bf39f483e34
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spelling	oai:doaj.org-article:b32e5963fa904384baa13bf39f483e342021-12-02T16:57:54ZActivation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation10.1038/s41467-019-11304-82041-1723https://doaj.org/article/b32e5963fa904384baa13bf39f483e342019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11304-8https://doaj.org/toc/2041-1723Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal inflammation.Jingyu LiWenli ShiHanxiao SunYan JiYuqin ChenXiaohuan GuoHuiming ShengJie ShuLiang ZhouTing CaiJu QiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingyu Li Wenli Shi Hanxiao Sun Yan Ji Yuqin Chen Xiaohuan Guo Huiming Sheng Jie Shu Liang Zhou Ting Cai Ju Qiu Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
description	Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal inflammation.
format	article
author	Jingyu Li Wenli Shi Hanxiao Sun Yan Ji Yuqin Chen Xiaohuan Guo Huiming Sheng Jie Shu Liang Zhou Ting Cai Ju Qiu
author_facet	Jingyu Li Wenli Shi Hanxiao Sun Yan Ji Yuqin Chen Xiaohuan Guo Huiming Sheng Jie Shu Liang Zhou Ting Cai Ju Qiu
author_sort	Jingyu Li
title	Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
title_short	Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
title_full	Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
title_fullStr	Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
title_full_unstemmed	Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
title_sort	activation of dr3 signaling causes loss of ilc3s and exacerbates intestinal inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b32e5963fa904384baa13bf39f483e34
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_version_	1718382465917124608

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

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