Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal in...

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Autores principales: Jingyu Li, Wenli Shi, Hanxiao Sun, Yan Ji, Yuqin Chen, Xiaohuan Guo, Huiming Sheng, Jie Shu, Liang Zhou, Ting Cai, Ju Qiu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/b32e5963fa904384baa13bf39f483e34
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