Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy

ABSTRACT The gut microbiota is an integral part of maintaining resistance against infection by Clostridioides (Clostridium) difficile, a pathogen of increasing concern in both health care and community settings. The recent article by J. M. Auchtung, E. C. Preisner, J. Collins, A. I. Lerma, and R. A....

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Autores principales:	Disha Bhattacharjee, Anna M. Seekatz
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	C. difficile FMT microbiota minibioreactors Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b3316919943d47149644a3def6e7def2
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spelling	oai:doaj.org-article:b3316919943d47149644a3def6e7def22021-11-15T15:30:52ZDilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy10.1128/mSphere.00701-202379-5042https://doaj.org/article/b3316919943d47149644a3def6e7def22020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00701-20https://doaj.org/toc/2379-5042ABSTRACT The gut microbiota is an integral part of maintaining resistance against infection by Clostridioides (Clostridium) difficile, a pathogen of increasing concern in both health care and community settings. The recent article by J. M. Auchtung, E. C. Preisner, J. Collins, A. I. Lerma, and R. A. Britton (mSphere 5:e00387-20, 2020, https://doi.org/10.1128/mSphere.00387-20) demonstrates an innovative approach to identify microbes that inhibit C. difficile by employing a dilution scheme to test different microbial mixtures in vitro and in vivo. This type of approach can advance the identification and validation of specific microbes that elicit functions of interest for many conditions involving the microbiota, of which the complexity and variability can often complicate causality.Disha BhattacharjeeAnna M. SeekatzAmerican Society for MicrobiologyarticleC. difficileFMTmicrobiotaminibioreactorsMicrobiologyQR1-502ENmSphere, Vol 5, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	C. difficile FMT microbiota minibioreactors Microbiology QR1-502
spellingShingle	C. difficile FMT microbiota minibioreactors Microbiology QR1-502 Disha Bhattacharjee Anna M. Seekatz Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
description	ABSTRACT The gut microbiota is an integral part of maintaining resistance against infection by Clostridioides (Clostridium) difficile, a pathogen of increasing concern in both health care and community settings. The recent article by J. M. Auchtung, E. C. Preisner, J. Collins, A. I. Lerma, and R. A. Britton (mSphere 5:e00387-20, 2020, https://doi.org/10.1128/mSphere.00387-20) demonstrates an innovative approach to identify microbes that inhibit C. difficile by employing a dilution scheme to test different microbial mixtures in vitro and in vivo. This type of approach can advance the identification and validation of specific microbes that elicit functions of interest for many conditions involving the microbiota, of which the complexity and variability can often complicate causality.
format	article
author	Disha Bhattacharjee Anna M. Seekatz
author_facet	Disha Bhattacharjee Anna M. Seekatz
author_sort	Disha Bhattacharjee
title	Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
title_short	Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
title_full	Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
title_fullStr	Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
title_full_unstemmed	Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy
title_sort	dilution as a solution: targeting microbial populations with a simplified dilution strategy
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/b3316919943d47149644a3def6e7def2
work_keys_str_mv	AT dishabhattacharjee dilutionasasolutiontargetingmicrobialpopulationswithasimplifieddilutionstrategy AT annamseekatz dilutionasasolutiontargetingmicrobialpopulationswithasimplifieddilutionstrategy
_version_	1718427907917873152

Dilution as a Solution: Targeting Microbial Populations with a Simplified Dilution Strategy

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