Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples

Nanopore sensors have long analysis times when analytes are at low concentration and non-specific signals in complex media. Here the authors use antibody-modified magnetic nanoparticles to detect prostate-specific antigen at sub-femtomolar concentrations in blood.

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Autores principales:	Kyloon Chuah, Yanfang Wu, S. R. C. Vivekchand, Katharina Gaus, Peter J. Reece, Adam P. Micolich, J. Justin Gooding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b333959b1b6b4d21b34449c128820b97
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spelling	oai:doaj.org-article:b333959b1b6b4d21b34449c128820b972021-12-02T17:01:40ZNanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples10.1038/s41467-019-10147-72041-1723https://doaj.org/article/b333959b1b6b4d21b34449c128820b972019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10147-7https://doaj.org/toc/2041-1723Nanopore sensors have long analysis times when analytes are at low concentration and non-specific signals in complex media. Here the authors use antibody-modified magnetic nanoparticles to detect prostate-specific antigen at sub-femtomolar concentrations in blood.Kyloon ChuahYanfang WuS. R. C. VivekchandKatharina GausPeter J. ReeceAdam P. MicolichJ. Justin GoodingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyloon Chuah Yanfang Wu S. R. C. Vivekchand Katharina Gaus Peter J. Reece Adam P. Micolich J. Justin Gooding Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
description	Nanopore sensors have long analysis times when analytes are at low concentration and non-specific signals in complex media. Here the authors use antibody-modified magnetic nanoparticles to detect prostate-specific antigen at sub-femtomolar concentrations in blood.
format	article
author	Kyloon Chuah Yanfang Wu S. R. C. Vivekchand Katharina Gaus Peter J. Reece Adam P. Micolich J. Justin Gooding
author_facet	Kyloon Chuah Yanfang Wu S. R. C. Vivekchand Katharina Gaus Peter J. Reece Adam P. Micolich J. Justin Gooding
author_sort	Kyloon Chuah
title	Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
title_short	Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
title_full	Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
title_fullStr	Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
title_full_unstemmed	Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
title_sort	nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b333959b1b6b4d21b34449c128820b97
work_keys_str_mv	AT kyloonchuah nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT yanfangwu nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT srcvivekchand nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT katharinagaus nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT peterjreece nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT adampmicolich nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples AT jjustingooding nanoporeblockadesensorsforultrasensitivedetectionofproteinsincomplexbiologicalsamples
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Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples

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