Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.

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Autores principales:	Tyler Risom, Ellen M. Langer, Margaret P. Chapman, Juha Rantala, Andrew J. Fields, Christopher Boniface, Mariano J. Alvarez, Nicholas D. Kendsersky, Carl R. Pelz, Katherine Johnson-Camacho, Lacey E. Dobrolecki, Koei Chin, Anil J. Aswani, Nicholas J. Wang, Andrea Califano, Michael T. Lewis, Claire J. Tomlin, Paul T. Spellman, Andrew Adey, Joe W. Gray, Rosalie C. Sears
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b334216fc1b74e778b875f012ede0e20
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spelling	oai:doaj.org-article:b334216fc1b74e778b875f012ede0e202021-12-02T16:50:06ZDifferentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer10.1038/s41467-018-05729-w2041-1723https://doaj.org/article/b334216fc1b74e778b875f012ede0e202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05729-whttps://doaj.org/toc/2041-1723Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.Tyler RisomEllen M. LangerMargaret P. ChapmanJuha RantalaAndrew J. FieldsChristopher BonifaceMariano J. AlvarezNicholas D. KendserskyCarl R. PelzKatherine Johnson-CamachoLacey E. DobroleckiKoei ChinAnil J. AswaniNicholas J. WangAndrea CalifanoMichael T. LewisClaire J. TomlinPaul T. SpellmanAndrew AdeyJoe W. GrayRosalie C. SearsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
description	Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.
format	article
author	Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears
author_facet	Tyler Risom Ellen M. Langer Margaret P. Chapman Juha Rantala Andrew J. Fields Christopher Boniface Mariano J. Alvarez Nicholas D. Kendsersky Carl R. Pelz Katherine Johnson-Camacho Lacey E. Dobrolecki Koei Chin Anil J. Aswani Nicholas J. Wang Andrea Califano Michael T. Lewis Claire J. Tomlin Paul T. Spellman Andrew Adey Joe W. Gray Rosalie C. Sears
author_sort	Tyler Risom
title	Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
title_short	Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
title_full	Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
title_fullStr	Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
title_full_unstemmed	Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
title_sort	differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b334216fc1b74e778b875f012ede0e20
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Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

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