Reconciling qualitative, abstract, and scalable modeling of biological networks

Boolean Networks are a well-established model of biological networks, but usual interpretations can preclude the prediction of behaviours observed in quantitative systems. The authors introduce Most Permissive Boolean Networks, which are shown not to miss any behaviour achievable by the correspondin...

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Autores principales: Loïc Paulevé, Juraj Kolčák, Thomas Chatain, Stefan Haar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b334f95a292b43fca9da83ea0ae7f1a2
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Sumario:Boolean Networks are a well-established model of biological networks, but usual interpretations can preclude the prediction of behaviours observed in quantitative systems. The authors introduce Most Permissive Boolean Networks, which are shown not to miss any behaviour achievable by the corresponding quantitative model.