Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review

Carmen Sílvia Miguel, Tiffany M Chaim-Avancini, Maria Aparecida Silva, Mario Rodrigues LouzãAdult Attention Deficit Hyperactivity Disorder Program (PRODATH), Institute of Psychiatry, University of São Paulo, São Paulo, BrazilBackground: The cogni...

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Autores principales:	Miguel CS, Chaim-Avancini TM, Silva MA, Louzã MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b33668c82ce747e78063e903bca003e0
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spelling	oai:doaj.org-article:b33668c82ce747e78063e903bca003e02021-12-02T05:34:20ZNeurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review1178-2021https://doaj.org/article/b33668c82ce747e78063e903bca003e02015-03-01T00:00:00Zhttp://www.dovepress.com/neurofibromatosis-type-1-and-attention-deficit-hyperactivity-disorder--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Carmen Sílvia Miguel, Tiffany M Chaim-Avancini, Maria Aparecida Silva, Mario Rodrigues LouzãAdult Attention Deficit Hyperactivity Disorder Program (PRODATH), Institute of Psychiatry, University of São Paulo, São Paulo, BrazilBackground: The cognitive profile of children with neurofibromatosis type 1 (NF1) and attention deficit hyperactivity disorder (ADHD) has been well characterized, but few studies have evaluated the cognitive abilities of adults with NF1 and ADHD.Objectives: We investigated 1) the cognitive profile of an adult patient with NF1 and inattention problems, 2) changes in his cognition after 14 months of follow-up, and 3) whether the patient exhibited comorbid NF1 and ADHD or secondary ADHD-like symptoms.Methods: We administered neuropsychological tests of executive function, attention, verbal and visual memory, visuospatial function, and language during two evaluations separated by 14 months.Results: We found no changes in sustained attention, language, or verbal memory. Visual memory, verbal learning, selective attention inhibitory control, and problem solving declined over time, whereas visual search, psychomotor speed, visuospatial function, and mental flexibility improved.Conclusion: Our patient exhibited a cognitive profile characteristic of both NF1 and ADHD, leading to the hypothesis that the patient had comorbid ADHD instead of secondary ADHD-like symptoms. More studies are necessary to characterize the cognition of patients with NF1 and ADHD.Keywords: ADHD, executive function, NF1, low-grade pontine glioma, cognitionMiguel CSChaim-Avancini TMSilva MALouzã MRDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 815-821 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Miguel CS Chaim-Avancini TM Silva MA Louzã MR Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
description	Carmen Sílvia Miguel, Tiffany M Chaim-Avancini, Maria Aparecida Silva, Mario Rodrigues LouzãAdult Attention Deficit Hyperactivity Disorder Program (PRODATH), Institute of Psychiatry, University of São Paulo, São Paulo, BrazilBackground: The cognitive profile of children with neurofibromatosis type 1 (NF1) and attention deficit hyperactivity disorder (ADHD) has been well characterized, but few studies have evaluated the cognitive abilities of adults with NF1 and ADHD.Objectives: We investigated 1) the cognitive profile of an adult patient with NF1 and inattention problems, 2) changes in his cognition after 14 months of follow-up, and 3) whether the patient exhibited comorbid NF1 and ADHD or secondary ADHD-like symptoms.Methods: We administered neuropsychological tests of executive function, attention, verbal and visual memory, visuospatial function, and language during two evaluations separated by 14 months.Results: We found no changes in sustained attention, language, or verbal memory. Visual memory, verbal learning, selective attention inhibitory control, and problem solving declined over time, whereas visual search, psychomotor speed, visuospatial function, and mental flexibility improved.Conclusion: Our patient exhibited a cognitive profile characteristic of both NF1 and ADHD, leading to the hypothesis that the patient had comorbid ADHD instead of secondary ADHD-like symptoms. More studies are necessary to characterize the cognition of patients with NF1 and ADHD.Keywords: ADHD, executive function, NF1, low-grade pontine glioma, cognition
format	article
author	Miguel CS Chaim-Avancini TM Silva MA Louzã MR
author_facet	Miguel CS Chaim-Avancini TM Silva MA Louzã MR
author_sort	Miguel CS
title	Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
title_short	Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
title_full	Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
title_fullStr	Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
title_full_unstemmed	Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
title_sort	neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b33668c82ce747e78063e903bca003e0
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Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review

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