Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999

Objective: Congestive heart failure and other cardiac complications are the most important causes of death in patients with beta Thalassemia major. Iron overloads and chronic anemia are the major causes of cardiac involvement. The purpose of this study was to evaluate the ability of echocardiographi...

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Autores principales:	A Ghaemian, M Kosarian, A Adhami
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2001
Materias:	thalassemia major echocardiography systolic function Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b339b3cd412848b48cd0212fd448d979
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spelling	oai:doaj.org-article:b339b3cd412848b48cd0212fd448d9792021-11-10T09:21:06ZEvaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 19991561-41072251-7170https://doaj.org/article/b339b3cd412848b48cd0212fd448d9792001-07-01T00:00:00Zhttp://jbums.org/article-1-2864-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Congestive heart failure and other cardiac complications are the most important causes of death in patients with beta Thalassemia major. Iron overloads and chronic anemia are the major causes of cardiac involvement. The purpose of this study was to evaluate the ability of echocardiographic systolic function for diagnosis of cardiac involvement in patients with Thalassemia major. Methods: This descriptive study was done on patients with Thalassemia major (Over 12 years old) who referred to Booali Sina hospital in Sari. They were evaluated according to their ages, sex, age at beginning of transfusion of deferoxamine, the amount of deferoxamine, serum ferritin level, clinical manifestations, electrocardiogram, chest radiography and echocardiographic systolic function. Data was statistically analyzed by T-test. Findings: 55% of patients were male and the average age was 18±6 years. 22% of patients had systolic dysfunction. The difference of ejection fraction and fractional shortening between patients with and without cardiac involvement was significant (p<0.000). The age at beginning of deferoxamine and ferritin level in patients with cardiac complication was greater. The evaluation of cardiac function for determining cardiac involvement in patients with Thalassemia major with respect to clinical manifestations had a specificity of 76%, sensitivity of 41% and efficacy of 68%. Conclusion: When the patient is clinically symptomatic, systolic function will be impaired. Evaluation of echocardiographic systolic function is not enough for determining cardiac involvement in asymptomatic patients.A GhaemianM KosarianA AdhamiBabol University of Medical Sciencesarticlethalassemia majorechocardiographysystolic functionMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 3, Iss 3, Pp 43-46 (2001)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia major echocardiography systolic function Medicine R Medicine (General) R5-920
spellingShingle	thalassemia major echocardiography systolic function Medicine R Medicine (General) R5-920 A Ghaemian M Kosarian A Adhami Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
description	Objective: Congestive heart failure and other cardiac complications are the most important causes of death in patients with beta Thalassemia major. Iron overloads and chronic anemia are the major causes of cardiac involvement. The purpose of this study was to evaluate the ability of echocardiographic systolic function for diagnosis of cardiac involvement in patients with Thalassemia major. Methods: This descriptive study was done on patients with Thalassemia major (Over 12 years old) who referred to Booali Sina hospital in Sari. They were evaluated according to their ages, sex, age at beginning of transfusion of deferoxamine, the amount of deferoxamine, serum ferritin level, clinical manifestations, electrocardiogram, chest radiography and echocardiographic systolic function. Data was statistically analyzed by T-test. Findings: 55% of patients were male and the average age was 18±6 years. 22% of patients had systolic dysfunction. The difference of ejection fraction and fractional shortening between patients with and without cardiac involvement was significant (p<0.000). The age at beginning of deferoxamine and ferritin level in patients with cardiac complication was greater. The evaluation of cardiac function for determining cardiac involvement in patients with Thalassemia major with respect to clinical manifestations had a specificity of 76%, sensitivity of 41% and efficacy of 68%. Conclusion: When the patient is clinically symptomatic, systolic function will be impaired. Evaluation of echocardiographic systolic function is not enough for determining cardiac involvement in asymptomatic patients.
format	article
author	A Ghaemian M Kosarian A Adhami
author_facet	A Ghaemian M Kosarian A Adhami
author_sort	A Ghaemian
title	Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
title_short	Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
title_full	Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
title_fullStr	Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
title_full_unstemmed	Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999
title_sort	evaluation of systolic function in patients with beta thalassemia major in booali sina hospital, sari, 1999
publisher	Babol University of Medical Sciences
publishDate	2001
url	https://doaj.org/article/b339b3cd412848b48cd0212fd448d979
work_keys_str_mv	AT aghaemian evaluationofsystolicfunctioninpatientswithbetathalassemiamajorinbooalisinahospitalsari1999 AT mkosarian evaluationofsystolicfunctioninpatientswithbetathalassemiamajorinbooalisinahospitalsari1999 AT aadhami evaluationofsystolicfunctioninpatientswithbetathalassemiamajorinbooalisinahospitalsari1999
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Evaluation of systolic function in patients with beta Thalassemia major in Booali Sina Hospital, Sari, 1999

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