Assessment of skin barrier function using skin images with topological data analysis

Abstract Recent developments of molecular biology have revealed diverse mechanisms of skin diseases, and precision medicine considering these mechanisms requires the frequent objective evaluation of skin phenotypes. Transepidermal water loss (TEWL) is commonly used for evaluating skin barrier functi...

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Autores principales:	Keita Koseki, Hiroshi Kawasaki, Toru Atsugi, Miki Nakanishi, Makoto Mizuno, Eiji Naru, Tamotsu Ebihara, Masayuki Amagai, Eiryo Kawakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b33d0e6ba53f419f8b09417e81465dec
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spelling	oai:doaj.org-article:b33d0e6ba53f419f8b09417e81465dec2021-12-02T13:58:16ZAssessment of skin barrier function using skin images with topological data analysis10.1038/s41540-020-00160-82056-7189https://doaj.org/article/b33d0e6ba53f419f8b09417e81465dec2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41540-020-00160-8https://doaj.org/toc/2056-7189Abstract Recent developments of molecular biology have revealed diverse mechanisms of skin diseases, and precision medicine considering these mechanisms requires the frequent objective evaluation of skin phenotypes. Transepidermal water loss (TEWL) is commonly used for evaluating skin barrier function; however, direct measurement of TEWL is time-consuming and is not convenient for daily clinical practice. Here, we propose a new skin barrier assessment method using skin images with topological data analysis (TDA). TDA enabled efficient identification of structural features from a skin image taken by a microscope. These features reflected the regularity of the skin texture. We found a significant correlation between the topological features and TEWL. Moreover, using the features as input, we trained machine-learning models to predict TEWL and obtained good accuracy (R 2 = 0.524). Our results suggest that assessment of skin barrier function by topological image analysis is promising.Keita KosekiHiroshi KawasakiToru AtsugiMiki NakanishiMakoto MizunoEiji NaruTamotsu EbiharaMasayuki AmagaiEiryo KawakamiNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 6, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Keita Koseki Hiroshi Kawasaki Toru Atsugi Miki Nakanishi Makoto Mizuno Eiji Naru Tamotsu Ebihara Masayuki Amagai Eiryo Kawakami Assessment of skin barrier function using skin images with topological data analysis
description	Abstract Recent developments of molecular biology have revealed diverse mechanisms of skin diseases, and precision medicine considering these mechanisms requires the frequent objective evaluation of skin phenotypes. Transepidermal water loss (TEWL) is commonly used for evaluating skin barrier function; however, direct measurement of TEWL is time-consuming and is not convenient for daily clinical practice. Here, we propose a new skin barrier assessment method using skin images with topological data analysis (TDA). TDA enabled efficient identification of structural features from a skin image taken by a microscope. These features reflected the regularity of the skin texture. We found a significant correlation between the topological features and TEWL. Moreover, using the features as input, we trained machine-learning models to predict TEWL and obtained good accuracy (R 2 = 0.524). Our results suggest that assessment of skin barrier function by topological image analysis is promising.
format	article
author	Keita Koseki Hiroshi Kawasaki Toru Atsugi Miki Nakanishi Makoto Mizuno Eiji Naru Tamotsu Ebihara Masayuki Amagai Eiryo Kawakami
author_facet	Keita Koseki Hiroshi Kawasaki Toru Atsugi Miki Nakanishi Makoto Mizuno Eiji Naru Tamotsu Ebihara Masayuki Amagai Eiryo Kawakami
author_sort	Keita Koseki
title	Assessment of skin barrier function using skin images with topological data analysis
title_short	Assessment of skin barrier function using skin images with topological data analysis
title_full	Assessment of skin barrier function using skin images with topological data analysis
title_fullStr	Assessment of skin barrier function using skin images with topological data analysis
title_full_unstemmed	Assessment of skin barrier function using skin images with topological data analysis
title_sort	assessment of skin barrier function using skin images with topological data analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b33d0e6ba53f419f8b09417e81465dec
work_keys_str_mv	AT keitakoseki assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT hiroshikawasaki assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT toruatsugi assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT mikinakanishi assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT makotomizuno assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT eijinaru assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT tamotsuebihara assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT masayukiamagai assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis AT eiryokawakami assessmentofskinbarrierfunctionusingskinimageswithtopologicaldataanalysis
_version_	1718392221902831616

Assessment of skin barrier function using skin images with topological data analysis

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