Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy

The present article discusses the characteristics and significance of content violation of key pro-inflammatory cytokines IL-8, TNFa, MCP-1 and key anti-inflammatory cytokine IL-10 during pro-inflammatory stage in patients with chronic heart failure (CHF), determined by dilated cardiomyopathy (31 pa...

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Autores principales:	K. A. Khamitova, A. N. Chepurnaya, V. I. Nikulicheva, G. S. Safuanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	chronic heart failure dilated cardiomyopathy ischemic cardiomyopathy ischemic heart failure il-8 il-10 tnfa mcp-1 Science Q
Acceso en línea:	https://doaj.org/article/b33d27fb1cbc4d22ba09e3caf7f4df67
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spelling	oai:doaj.org-article:b33d27fb1cbc4d22ba09e3caf7f4df672021-11-23T06:14:37ZContent of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy2541-94202587-959610.12737/article_59f035fb165998.71029228https://doaj.org/article/b33d27fb1cbc4d22ba09e3caf7f4df672017-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/389https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The present article discusses the characteristics and significance of content violation of key pro-inflammatory cytokines IL-8, TNFa, MCP-1 and key anti-inflammatory cytokine IL-10 during pro-inflammatory stage in patients with chronic heart failure (CHF), determined by dilated cardiomyopathy (31 patient) and in CHF patients with coronary heart disease (CHD) (29 patients). EIA method with enzyme immune test systems (ZAO "Vector Best") and analyser ACCESS was used to assess the content of cytokines in the blood. The results of the study showed significant reduction of IL-8, increase of TNFa, MCP-1 and IL-10. Violation of adequate response of cytokines in pro-inflammatory stage enables to consider this disorder as a pathogenic unfavorable factor, leading to CHF progression in patients with dilated cardiomyopathy and CHD. Comparison of the parameters of cardiac hemodynamics, differential white blood cell count and correlation results proves that heart failure in patients with dilated cardiomyopathy and CHD have similar pathogenic origins of chronic inflammatory process. Imbalance of IL-8, TNFa, MCP-1 and IL-10 does not provide protection from inflammatory and bacterial antigens. In case of inadequate and protracted inflammatory reaction, decreased cytokine-producing leukocyte function can destroy myocardium. Results of correlation analysis prove violation of linear connection andformation of atypical correlations between TNFa and TNFa monocytes and neutrophils, IL-8 and monocytes, TNFa and IL-10, IL-10 and lymphocytes, IL-10 and TNFa, IL-8 and IL-10. Increased production of TNFa, MCP-1 in combination with decreased IL-8 and increased IL-10 indicates staging violation accompanied by delay of transition of pro-inflammatory stage into anti-inflammatory one.K. A. KhamitovaA. N. ChepurnayaV. I. NikulichevaG. S. SafuanovaScientific Сentre for Family Health and Human Reproduction Problemsarticlechronic heart failuredilated cardiomyopathyischemic cardiomyopathyischemic heart failureil-8il-10tnfamcp-1ScienceQRUActa Biomedica Scientifica, Vol 2, Iss 3, Pp 48-54 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic heart failure dilated cardiomyopathy ischemic cardiomyopathy ischemic heart failure il-8 il-10 tnfa mcp-1 Science Q
spellingShingle	chronic heart failure dilated cardiomyopathy ischemic cardiomyopathy ischemic heart failure il-8 il-10 tnfa mcp-1 Science Q K. A. Khamitova A. N. Chepurnaya V. I. Nikulicheva G. S. Safuanova Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
description	The present article discusses the characteristics and significance of content violation of key pro-inflammatory cytokines IL-8, TNFa, MCP-1 and key anti-inflammatory cytokine IL-10 during pro-inflammatory stage in patients with chronic heart failure (CHF), determined by dilated cardiomyopathy (31 patient) and in CHF patients with coronary heart disease (CHD) (29 patients). EIA method with enzyme immune test systems (ZAO "Vector Best") and analyser ACCESS was used to assess the content of cytokines in the blood. The results of the study showed significant reduction of IL-8, increase of TNFa, MCP-1 and IL-10. Violation of adequate response of cytokines in pro-inflammatory stage enables to consider this disorder as a pathogenic unfavorable factor, leading to CHF progression in patients with dilated cardiomyopathy and CHD. Comparison of the parameters of cardiac hemodynamics, differential white blood cell count and correlation results proves that heart failure in patients with dilated cardiomyopathy and CHD have similar pathogenic origins of chronic inflammatory process. Imbalance of IL-8, TNFa, MCP-1 and IL-10 does not provide protection from inflammatory and bacterial antigens. In case of inadequate and protracted inflammatory reaction, decreased cytokine-producing leukocyte function can destroy myocardium. Results of correlation analysis prove violation of linear connection andformation of atypical correlations between TNFa and TNFa monocytes and neutrophils, IL-8 and monocytes, TNFa and IL-10, IL-10 and lymphocytes, IL-10 and TNFa, IL-8 and IL-10. Increased production of TNFa, MCP-1 in combination with decreased IL-8 and increased IL-10 indicates staging violation accompanied by delay of transition of pro-inflammatory stage into anti-inflammatory one.
format	article
author	K. A. Khamitova A. N. Chepurnaya V. I. Nikulicheva G. S. Safuanova
author_facet	K. A. Khamitova A. N. Chepurnaya V. I. Nikulicheva G. S. Safuanova
author_sort	K. A. Khamitova
title	Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
title_short	Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
title_full	Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
title_fullStr	Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
title_full_unstemmed	Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
title_sort	content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/b33d27fb1cbc4d22ba09e3caf7f4df67
work_keys_str_mv	AT kakhamitova contentofcytokineinflammatorymarkersinpatientswithchronicheartfailurecausedbycardiomyopathy AT anchepurnaya contentofcytokineinflammatorymarkersinpatientswithchronicheartfailurecausedbycardiomyopathy AT vinikulicheva contentofcytokineinflammatorymarkersinpatientswithchronicheartfailurecausedbycardiomyopathy AT gssafuanova contentofcytokineinflammatorymarkersinpatientswithchronicheartfailurecausedbycardiomyopathy
_version_	1718417028399759360

Content of cytokine inflammatory markers in patients with chronic heart failure caused by cardiomyopathy

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