Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection

Abstract Protecting surfaces from bacterial colonization and biofilm development is an important challenge for the medical sector, particularly when it comes to biomedical devices and implants that spend longer periods in contact with the human body. A particularly difficult challenge is ensuring lo...

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Autores principales:	Santosh Pandit, Shadi Rahimi, Abderahmane Derouiche, Athmane Boulaoued, Ivan Mijakovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b33d88fd73cc4c318db30986a6ed611f
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spelling	oai:doaj.org-article:b33d88fd73cc4c318db30986a6ed611f2021-12-02T16:57:37ZSustained release of usnic acid from graphene coatings ensures long term antibiofilm protection10.1038/s41598-021-89452-52045-2322https://doaj.org/article/b33d88fd73cc4c318db30986a6ed611f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89452-5https://doaj.org/toc/2045-2322Abstract Protecting surfaces from bacterial colonization and biofilm development is an important challenge for the medical sector, particularly when it comes to biomedical devices and implants that spend longer periods in contact with the human body. A particularly difficult challenge is ensuring long-term protection, which is usually attempted by ensuring sustained release of antibacterial compounds loaded onto various coatings. Graphene have a considerable potential to reversibly interact water insoluble molecules, which makes them promising cargo systems for sustained release of such compounds. In this study, we developed graphene coatings that act as carriers capable of sustained release of usnic acid (UA), and hence enable long-term protection of surfaces against colonization by bacterial pathogens Staphylococcus aureus and Staphylococcus epidermidis. Our coatings exhibited several features that made them particularly effective for antibiofilm protection: (i) UA was successfully integrated with the graphene material, (ii) a steady release of UA was documented, (iii) steady UA release ensured strong inhibition of bacterial biofilm formation. Interestingly, even after the initial burst release of UA, the second phase of steady release was sufficient to block bacterial colonization. Based on these results, we propose that graphene coatings loaded with UA can serve as effective antibiofilm protection of biomedical surfaces.Santosh PanditShadi RahimiAbderahmane DerouicheAthmane BoulaouedIvan MijakovicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Santosh Pandit Shadi Rahimi Abderahmane Derouiche Athmane Boulaoued Ivan Mijakovic Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
description	Abstract Protecting surfaces from bacterial colonization and biofilm development is an important challenge for the medical sector, particularly when it comes to biomedical devices and implants that spend longer periods in contact with the human body. A particularly difficult challenge is ensuring long-term protection, which is usually attempted by ensuring sustained release of antibacterial compounds loaded onto various coatings. Graphene have a considerable potential to reversibly interact water insoluble molecules, which makes them promising cargo systems for sustained release of such compounds. In this study, we developed graphene coatings that act as carriers capable of sustained release of usnic acid (UA), and hence enable long-term protection of surfaces against colonization by bacterial pathogens Staphylococcus aureus and Staphylococcus epidermidis. Our coatings exhibited several features that made them particularly effective for antibiofilm protection: (i) UA was successfully integrated with the graphene material, (ii) a steady release of UA was documented, (iii) steady UA release ensured strong inhibition of bacterial biofilm formation. Interestingly, even after the initial burst release of UA, the second phase of steady release was sufficient to block bacterial colonization. Based on these results, we propose that graphene coatings loaded with UA can serve as effective antibiofilm protection of biomedical surfaces.
format	article
author	Santosh Pandit Shadi Rahimi Abderahmane Derouiche Athmane Boulaoued Ivan Mijakovic
author_facet	Santosh Pandit Shadi Rahimi Abderahmane Derouiche Athmane Boulaoued Ivan Mijakovic
author_sort	Santosh Pandit
title	Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
title_short	Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
title_full	Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
title_fullStr	Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
title_full_unstemmed	Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
title_sort	sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b33d88fd73cc4c318db30986a6ed611f
work_keys_str_mv	AT santoshpandit sustainedreleaseofusnicacidfromgraphenecoatingsensureslongtermantibiofilmprotection AT shadirahimi sustainedreleaseofusnicacidfromgraphenecoatingsensureslongtermantibiofilmprotection AT abderahmanederouiche sustainedreleaseofusnicacidfromgraphenecoatingsensureslongtermantibiofilmprotection AT athmaneboulaoued sustainedreleaseofusnicacidfromgraphenecoatingsensureslongtermantibiofilmprotection AT ivanmijakovic sustainedreleaseofusnicacidfromgraphenecoatingsensureslongtermantibiofilmprotection
_version_	1718382524815638528

Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection

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