Synthetic chimeric nucleases function for efficient genome editing

CRISPR-Cas systems have well characterized, modular structures. Here the authors use that architecture to design a Cas12a library of 560 synthetic chimeras, with altered PAM preferences and specificities.

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Autores principales:	R. M. Liu, L. L. Liang, E. Freed, H. Chang, E. Oh, Z. Y. Liu, A. Garst, C. A. Eckert, R. T. Gill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3426a5c4a194f89b3f9de6d909729e5
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spelling	oai:doaj.org-article:b3426a5c4a194f89b3f9de6d909729e52021-12-02T14:35:31ZSynthetic chimeric nucleases function for efficient genome editing10.1038/s41467-019-13500-y2041-1723https://doaj.org/article/b3426a5c4a194f89b3f9de6d909729e52019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13500-yhttps://doaj.org/toc/2041-1723CRISPR-Cas systems have well characterized, modular structures. Here the authors use that architecture to design a Cas12a library of 560 synthetic chimeras, with altered PAM preferences and specificities.R. M. LiuL. L. LiangE. FreedH. ChangE. OhZ. Y. LiuA. GarstC. A. EckertR. T. GillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. M. Liu L. L. Liang E. Freed H. Chang E. Oh Z. Y. Liu A. Garst C. A. Eckert R. T. Gill Synthetic chimeric nucleases function for efficient genome editing
description	CRISPR-Cas systems have well characterized, modular structures. Here the authors use that architecture to design a Cas12a library of 560 synthetic chimeras, with altered PAM preferences and specificities.
format	article
author	R. M. Liu L. L. Liang E. Freed H. Chang E. Oh Z. Y. Liu A. Garst C. A. Eckert R. T. Gill
author_facet	R. M. Liu L. L. Liang E. Freed H. Chang E. Oh Z. Y. Liu A. Garst C. A. Eckert R. T. Gill
author_sort	R. M. Liu
title	Synthetic chimeric nucleases function for efficient genome editing
title_short	Synthetic chimeric nucleases function for efficient genome editing
title_full	Synthetic chimeric nucleases function for efficient genome editing
title_fullStr	Synthetic chimeric nucleases function for efficient genome editing
title_full_unstemmed	Synthetic chimeric nucleases function for efficient genome editing
title_sort	synthetic chimeric nucleases function for efficient genome editing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b3426a5c4a194f89b3f9de6d909729e5
work_keys_str_mv	AT rmliu syntheticchimericnucleasesfunctionforefficientgenomeediting AT llliang syntheticchimericnucleasesfunctionforefficientgenomeediting AT efreed syntheticchimericnucleasesfunctionforefficientgenomeediting AT hchang syntheticchimericnucleasesfunctionforefficientgenomeediting AT eoh syntheticchimericnucleasesfunctionforefficientgenomeediting AT zyliu syntheticchimericnucleasesfunctionforefficientgenomeediting AT agarst syntheticchimericnucleasesfunctionforefficientgenomeediting AT caeckert syntheticchimericnucleasesfunctionforefficientgenomeediting AT rtgill syntheticchimericnucleasesfunctionforefficientgenomeediting
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Synthetic chimeric nucleases function for efficient genome editing

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