Chimpanzee malaria parasites related to Plasmodium ovale in Africa.

Since the 1970's, the diversity of Plasmodium parasites in African great apes has been neglected. Surprisingly, P. reichenowi, a chimpanzee parasite, is the only such parasite to have been molecularly characterized. This parasite is closely phylogenetically related to P. falciparum, the princip...

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Autores principales:	Linda Duval, Eric Nerrienet, Dominique Rousset, Serge Alain Sadeuh Mba, Sandrine Houze, Mathieu Fourment, Jacques Le Bras, Vincent Robert, Frederic Ariey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b344f963caf148e992829ca7a2abb6de
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spelling	oai:doaj.org-article:b344f963caf148e992829ca7a2abb6de2021-11-25T06:22:43ZChimpanzee malaria parasites related to Plasmodium ovale in Africa.1932-620310.1371/journal.pone.0005520https://doaj.org/article/b344f963caf148e992829ca7a2abb6de2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19436742/?tool=EBIhttps://doaj.org/toc/1932-6203Since the 1970's, the diversity of Plasmodium parasites in African great apes has been neglected. Surprisingly, P. reichenowi, a chimpanzee parasite, is the only such parasite to have been molecularly characterized. This parasite is closely phylogenetically related to P. falciparum, the principal cause of the greatest malaria burden in humans. Studies of malaria parasites from anthropoid primates may provide relevant phylogenetic information, improving our understanding of the origin and evolutionary history of human malaria species. In this study, we screened 130 DNA samples from chimpanzees (Pan troglodytes) and gorillas (Gorilla gorilla) from Cameroon for Plasmodium infection, using cytochrome b molecular tools. Two chimpanzees from the subspecies Pan t. troglodytes presented single infections with Plasmodium strains molecularly related to the human malaria parasite P. ovale. These chimpanzee parasites and 13 human strains of P. ovale originated from a various sites in Africa and Asia were characterized using cytochrome b and cytochrome c oxidase 1 mitochondrial partial genes and nuclear ldh partial gene. Consistent with previous findings, two genetically distinct types of P. ovale, classical and variant, were observed in the human population from a variety of geographical locations. One chimpanzee Plasmodium strain was genetically identical, on all three markers tested, to variant P. ovale type. The other chimpanzee Plasmodium strain was different from P. ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes.Linda DuvalEric NerrienetDominique RoussetSerge Alain Sadeuh MbaSandrine HouzeMathieu FourmentJacques Le BrasVincent RobertFrederic ArieyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 5, p e5520 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda Duval Eric Nerrienet Dominique Rousset Serge Alain Sadeuh Mba Sandrine Houze Mathieu Fourment Jacques Le Bras Vincent Robert Frederic Ariey Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
description	Since the 1970's, the diversity of Plasmodium parasites in African great apes has been neglected. Surprisingly, P. reichenowi, a chimpanzee parasite, is the only such parasite to have been molecularly characterized. This parasite is closely phylogenetically related to P. falciparum, the principal cause of the greatest malaria burden in humans. Studies of malaria parasites from anthropoid primates may provide relevant phylogenetic information, improving our understanding of the origin and evolutionary history of human malaria species. In this study, we screened 130 DNA samples from chimpanzees (Pan troglodytes) and gorillas (Gorilla gorilla) from Cameroon for Plasmodium infection, using cytochrome b molecular tools. Two chimpanzees from the subspecies Pan t. troglodytes presented single infections with Plasmodium strains molecularly related to the human malaria parasite P. ovale. These chimpanzee parasites and 13 human strains of P. ovale originated from a various sites in Africa and Asia were characterized using cytochrome b and cytochrome c oxidase 1 mitochondrial partial genes and nuclear ldh partial gene. Consistent with previous findings, two genetically distinct types of P. ovale, classical and variant, were observed in the human population from a variety of geographical locations. One chimpanzee Plasmodium strain was genetically identical, on all three markers tested, to variant P. ovale type. The other chimpanzee Plasmodium strain was different from P. ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes.
format	article
author	Linda Duval Eric Nerrienet Dominique Rousset Serge Alain Sadeuh Mba Sandrine Houze Mathieu Fourment Jacques Le Bras Vincent Robert Frederic Ariey
author_facet	Linda Duval Eric Nerrienet Dominique Rousset Serge Alain Sadeuh Mba Sandrine Houze Mathieu Fourment Jacques Le Bras Vincent Robert Frederic Ariey
author_sort	Linda Duval
title	Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
title_short	Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
title_full	Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
title_fullStr	Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
title_full_unstemmed	Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
title_sort	chimpanzee malaria parasites related to plasmodium ovale in africa.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/b344f963caf148e992829ca7a2abb6de
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Chimpanzee malaria parasites related to Plasmodium ovale in Africa.

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