Effects of Echo Time on IVIM Quantification of the Normal Prostate

Abstract The two-compartment intravoxel incoherent motion (IVIM) theory assumes that the transverse relaxation time is the same in both compartments. However, blood and tissue have different T2 values, and echo time (TE) may thus have an effect on the quantitative parameters of IVIM. The purpose of...

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Autores principales:	Zhaoyan Feng, Xiangde Min, Liang Wang, Xu Yan, Basen Li, Zan Ke, Peipei Zhang, Huijuan You
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3459ef4f8124bf3b71d739df7f0c1ad
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spelling	oai:doaj.org-article:b3459ef4f8124bf3b71d739df7f0c1ad2021-12-02T15:08:11ZEffects of Echo Time on IVIM Quantification of the Normal Prostate10.1038/s41598-018-19150-22045-2322https://doaj.org/article/b3459ef4f8124bf3b71d739df7f0c1ad2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19150-2https://doaj.org/toc/2045-2322Abstract The two-compartment intravoxel incoherent motion (IVIM) theory assumes that the transverse relaxation time is the same in both compartments. However, blood and tissue have different T2 values, and echo time (TE) may thus have an effect on the quantitative parameters of IVIM. The purpose of this study was to investigate the effects of TE on IVIM-DWI-derived parameters of the prostate. In total, 17 healthy volunteers underwent two repeat examinations. IVIM-DWI data were scanned 6 times with variable TE values of 60, 70, 80, 90, 100, and 120 ms. The ADC of a mono-exponential model and the D, D*, and f parameters of the IVIM model were calculated separately for each TE. Repeat measures were assessed by calculating the coefficient of variation and Bland-Altman limits of agreement for each parameter. Spearman’s rho test was used to analyse relationships between IVIM indices and TE. Our results showed that TE had an effect on IVIM quantification, which should be kept constant in the examination protocol at each individual institution. Alternatively, an extended IVIM could be used to eliminate the effect of the TE value on the quantitative parameters of IVIM. This may be helpful for guiding clinical research, especially for longitudinal studies.Zhaoyan FengXiangde MinLiang WangXu YanBasen LiZan KePeipei ZhangHuijuan YouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhaoyan Feng Xiangde Min Liang Wang Xu Yan Basen Li Zan Ke Peipei Zhang Huijuan You Effects of Echo Time on IVIM Quantification of the Normal Prostate
description	Abstract The two-compartment intravoxel incoherent motion (IVIM) theory assumes that the transverse relaxation time is the same in both compartments. However, blood and tissue have different T2 values, and echo time (TE) may thus have an effect on the quantitative parameters of IVIM. The purpose of this study was to investigate the effects of TE on IVIM-DWI-derived parameters of the prostate. In total, 17 healthy volunteers underwent two repeat examinations. IVIM-DWI data were scanned 6 times with variable TE values of 60, 70, 80, 90, 100, and 120 ms. The ADC of a mono-exponential model and the D, D*, and f parameters of the IVIM model were calculated separately for each TE. Repeat measures were assessed by calculating the coefficient of variation and Bland-Altman limits of agreement for each parameter. Spearman’s rho test was used to analyse relationships between IVIM indices and TE. Our results showed that TE had an effect on IVIM quantification, which should be kept constant in the examination protocol at each individual institution. Alternatively, an extended IVIM could be used to eliminate the effect of the TE value on the quantitative parameters of IVIM. This may be helpful for guiding clinical research, especially for longitudinal studies.
format	article
author	Zhaoyan Feng Xiangde Min Liang Wang Xu Yan Basen Li Zan Ke Peipei Zhang Huijuan You
author_facet	Zhaoyan Feng Xiangde Min Liang Wang Xu Yan Basen Li Zan Ke Peipei Zhang Huijuan You
author_sort	Zhaoyan Feng
title	Effects of Echo Time on IVIM Quantification of the Normal Prostate
title_short	Effects of Echo Time on IVIM Quantification of the Normal Prostate
title_full	Effects of Echo Time on IVIM Quantification of the Normal Prostate
title_fullStr	Effects of Echo Time on IVIM Quantification of the Normal Prostate
title_full_unstemmed	Effects of Echo Time on IVIM Quantification of the Normal Prostate
title_sort	effects of echo time on ivim quantification of the normal prostate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3459ef4f8124bf3b71d739df7f0c1ad
work_keys_str_mv	AT zhaoyanfeng effectsofechotimeonivimquantificationofthenormalprostate AT xiangdemin effectsofechotimeonivimquantificationofthenormalprostate AT liangwang effectsofechotimeonivimquantificationofthenormalprostate AT xuyan effectsofechotimeonivimquantificationofthenormalprostate AT basenli effectsofechotimeonivimquantificationofthenormalprostate AT zanke effectsofechotimeonivimquantificationofthenormalprostate AT peipeizhang effectsofechotimeonivimquantificationofthenormalprostate AT huijuanyou effectsofechotimeonivimquantificationofthenormalprostate
_version_	1718388274417893376

Effects of Echo Time on IVIM Quantification of the Normal Prostate

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