Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

Emilie Cousin1, Monica Baciu1, C&eacute;dric Pichat1, Philippe Kahane2, Jean-Fran&ccedil;ois Le Bas31UMR CNRS/UPMF 5105, Laboratoire de Psychologie et Neurocognition; 2Laboratoire de Neurophysiopathologie de l&rsquo;Epilepsie, CHU Grenoble; 3Unit&eacute; IRM, CHU Gren...

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Autores principales:	Emilie Cousin, Monica Baciu, C&eacute;dric Pichat1, Philippe Kahane, Jean-Fran&ccedil;ois Le Bas
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b3462198c983432294f9f08d1281d58a
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spelling	oai:doaj.org-article:b3462198c983432294f9f08d1281d58a2021-12-02T03:30:33ZFunctional MRI evidence for language plasticity in adult epileptic patients: Preliminary results1176-63281178-2021https://doaj.org/article/b3462198c983432294f9f08d1281d58a2008-03-01T00:00:00Zhttp://www.dovepress.com/functional-mri-evidence-for-language-plasticity-in-adult-epileptic-pat-a1005https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Emilie Cousin1, Monica Baciu1, C&eacute;dric Pichat1, Philippe Kahane2, Jean-Fran&ccedil;ois Le Bas31UMR CNRS/UPMF 5105, Laboratoire de Psychologie et Neurocognition; 2Laboratoire de Neurophysiopathologie de l&rsquo;Epilepsie, CHU Grenoble; 3Unit&eacute; IRM, CHU Grenoble, FranceAbstract: The present fMRI study explores the cerebral reorganisation of language in patients with temporal lobe epilepsy, according to the age of seizures onset (early or late) and the hippocampal sclerosis (associated or not). Seven right-handed control volunteers and seven preoperative adult epileptic patients performed a rhyme decision (language condition) and a visual detection (control condition) tasks in visually presented words and unreadable characters, respectively. All patients were left hemisphere dominant for language. Appropriate statistical analyses provided the following preliminary results: (1) patients compared with healthy subjects showed lower degree of hemispheric lateralization with supplementary involvement of the right hemisphere; (2) the degree of hemispheric specialization depends on the considered region; (3) patients with early seizures show signs of temporal and parietal reorganization more frequently than patients with late onset of seizures; (4) patients with early seizures show a tendency for intra-hemispheric frontal reorganisation; (5) associated hippocampal sclerosis facilitates the inter-hemispheric shift of temporal activation. Although our patients were left hemisphere predominant for language, the statistical analyses indicated that the degree of lateralization was significantly lower than in healthy subjects. This result has been considered as the indication of atypical lateralization of language.Keywords: language, fMRI, plasticity, temporal epilepsy, age, hippocampal sclerosis Emilie CousinMonica BaciuC&eacute;dric Pichat1Philippe KahaneJean-Fran&ccedil;ois Le BasDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 235-246 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Emilie Cousin Monica Baciu C&eacute;dric Pichat1 Philippe Kahane Jean-Fran&ccedil;ois Le Bas Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
description	Emilie Cousin1, Monica Baciu1, C&eacute;dric Pichat1, Philippe Kahane2, Jean-Fran&ccedil;ois Le Bas31UMR CNRS/UPMF 5105, Laboratoire de Psychologie et Neurocognition; 2Laboratoire de Neurophysiopathologie de l&rsquo;Epilepsie, CHU Grenoble; 3Unit&eacute; IRM, CHU Grenoble, FranceAbstract: The present fMRI study explores the cerebral reorganisation of language in patients with temporal lobe epilepsy, according to the age of seizures onset (early or late) and the hippocampal sclerosis (associated or not). Seven right-handed control volunteers and seven preoperative adult epileptic patients performed a rhyme decision (language condition) and a visual detection (control condition) tasks in visually presented words and unreadable characters, respectively. All patients were left hemisphere dominant for language. Appropriate statistical analyses provided the following preliminary results: (1) patients compared with healthy subjects showed lower degree of hemispheric lateralization with supplementary involvement of the right hemisphere; (2) the degree of hemispheric specialization depends on the considered region; (3) patients with early seizures show signs of temporal and parietal reorganization more frequently than patients with late onset of seizures; (4) patients with early seizures show a tendency for intra-hemispheric frontal reorganisation; (5) associated hippocampal sclerosis facilitates the inter-hemispheric shift of temporal activation. Although our patients were left hemisphere predominant for language, the statistical analyses indicated that the degree of lateralization was significantly lower than in healthy subjects. This result has been considered as the indication of atypical lateralization of language.Keywords: language, fMRI, plasticity, temporal epilepsy, age, hippocampal sclerosis
format	article
author	Emilie Cousin Monica Baciu C&eacute;dric Pichat1 Philippe Kahane Jean-Fran&ccedil;ois Le Bas
author_facet	Emilie Cousin Monica Baciu C&eacute;dric Pichat1 Philippe Kahane Jean-Fran&ccedil;ois Le Bas
author_sort	Emilie Cousin
title	Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
title_short	Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
title_full	Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
title_fullStr	Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
title_full_unstemmed	Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results
title_sort	functional mri evidence for language plasticity in adult epileptic patients: preliminary results
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b3462198c983432294f9f08d1281d58a
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Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

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