Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts

Gene fusion, trans-splicing or transcription read-through contributes to generation of chimeric RNA. Here the authors develop a pipeline to identify non-canonical type of chimeric RNAs called cross-strand chimeric RNA (cscRNA), which are fused between two precursor RNAs transcribed from the opposite...

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Auteurs principaux: Yuting Wang, Qin Zou, Fajin Li, Wenwei Zhao, Hui Xu, Wenhao Zhang, Haiteng Deng, Xuerui Yang
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/b34a95e3375e4146a8fc28a8bf1d6036
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Résumé:Gene fusion, trans-splicing or transcription read-through contributes to generation of chimeric RNA. Here the authors develop a pipeline to identify non-canonical type of chimeric RNAs called cross-strand chimeric RNA (cscRNA), which are fused between two precursor RNAs transcribed from the opposite DNA strands.