Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of cancer association.

Guardado en:
Detalles Bibliográficos
Autores principales: P. Savola, T. Kelkka, H. L. Rajala, A. Kuuliala, K. Kuuliala, S. Eldfors, P. Ellonen, S. Lagström, M. Lepistö, T. Hannunen, E. I. Andersson, R. K. Khajuria, T. Jaatinen, R. Koivuniemi, H. Repo, J. Saarela, K. Porkka, M. Leirisalo-Repo, S. Mustjoki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b34d9e4915724e738eb008462bd3f4e7
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b34d9e4915724e738eb008462bd3f4e7
record_format dspace
spelling oai:doaj.org-article:b34d9e4915724e738eb008462bd3f4e72021-12-02T15:38:33ZSomatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis10.1038/ncomms158692041-1723https://doaj.org/article/b34d9e4915724e738eb008462bd3f4e72017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15869https://doaj.org/toc/2041-1723Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of cancer association.P. SavolaT. KelkkaH. L. RajalaA. KuulialaK. KuulialaS. EldforsP. EllonenS. LagströmM. LepistöT. HannunenE. I. AnderssonR. K. KhajuriaT. JaatinenR. KoivuniemiH. RepoJ. SaarelaK. PorkkaM. Leirisalo-RepoS. MustjokiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
P. Savola
T. Kelkka
H. L. Rajala
A. Kuuliala
K. Kuuliala
S. Eldfors
P. Ellonen
S. Lagström
M. Lepistö
T. Hannunen
E. I. Andersson
R. K. Khajuria
T. Jaatinen
R. Koivuniemi
H. Repo
J. Saarela
K. Porkka
M. Leirisalo-Repo
S. Mustjoki
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
description Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of cancer association.
format article
author P. Savola
T. Kelkka
H. L. Rajala
A. Kuuliala
K. Kuuliala
S. Eldfors
P. Ellonen
S. Lagström
M. Lepistö
T. Hannunen
E. I. Andersson
R. K. Khajuria
T. Jaatinen
R. Koivuniemi
H. Repo
J. Saarela
K. Porkka
M. Leirisalo-Repo
S. Mustjoki
author_facet P. Savola
T. Kelkka
H. L. Rajala
A. Kuuliala
K. Kuuliala
S. Eldfors
P. Ellonen
S. Lagström
M. Lepistö
T. Hannunen
E. I. Andersson
R. K. Khajuria
T. Jaatinen
R. Koivuniemi
H. Repo
J. Saarela
K. Porkka
M. Leirisalo-Repo
S. Mustjoki
author_sort P. Savola
title Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
title_short Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
title_full Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
title_fullStr Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
title_full_unstemmed Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
title_sort somatic mutations in clonally expanded cytotoxic t lymphocytes in patients with newly diagnosed rheumatoid arthritis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b34d9e4915724e738eb008462bd3f4e7
work_keys_str_mv AT psavola somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT tkelkka somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT hlrajala somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT akuuliala somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT kkuuliala somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT seldfors somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT pellonen somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT slagstrom somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT mlepisto somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT thannunen somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT eiandersson somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT rkkhajuria somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT tjaatinen somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT rkoivuniemi somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT hrepo somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT jsaarela somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT kporkka somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT mleirisalorepo somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
AT smustjoki somaticmutationsinclonallyexpandedcytotoxictlymphocytesinpatientswithnewlydiagnosedrheumatoidarthritis
_version_ 1718386195416743936

Ejemplares similares