Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study

Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properti...

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Autores principales:	Manuel Toledano-Osorio, Raquel Osorio, Estrella Osorio, Antonio L. Medina-Castillo, Manuel Toledano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoparticles zinc dentin hypersensitivity dentinal tubules dentifrice Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b34efdbaf6da49829621394c3532d6c1
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spelling	oai:doaj.org-article:b34efdbaf6da49829621394c3532d6c12021-11-25T18:32:50ZNovel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study10.3390/nano111131502079-4991https://doaj.org/article/b34efdbaf6da49829621394c3532d6c12021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/3150https://doaj.org/toc/2079-4991Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne<sup>®</sup>. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (<i>p</i> < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne<sup>®</sup> have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne<sup>®</sup>, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin.Manuel Toledano-OsorioRaquel OsorioEstrella OsorioAntonio L. Medina-CastilloManuel ToledanoMDPI AGarticlenanoparticleszincdentin hypersensitivitydentinal tubulesdentifriceChemistryQD1-999ENNanomaterials, Vol 11, Iss 3150, p 3150 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles zinc dentin hypersensitivity dentinal tubules dentifrice Chemistry QD1-999
spellingShingle	nanoparticles zinc dentin hypersensitivity dentinal tubules dentifrice Chemistry QD1-999 Manuel Toledano-Osorio Raquel Osorio Estrella Osorio Antonio L. Medina-Castillo Manuel Toledano Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
description	Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne<sup>®</sup>. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (<i>p</i> < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne<sup>®</sup> have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne<sup>®</sup>, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin.
format	article
author	Manuel Toledano-Osorio Raquel Osorio Estrella Osorio Antonio L. Medina-Castillo Manuel Toledano
author_facet	Manuel Toledano-Osorio Raquel Osorio Estrella Osorio Antonio L. Medina-Castillo Manuel Toledano
author_sort	Manuel Toledano-Osorio
title	Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
title_short	Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
title_full	Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
title_fullStr	Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
title_full_unstemmed	Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study
title_sort	novel pastes containing polymeric nanoparticles for dentin hypersensitivity treatment: an in vitro study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b34efdbaf6da49829621394c3532d6c1
work_keys_str_mv	AT manueltoledanoosorio novelpastescontainingpolymericnanoparticlesfordentinhypersensitivitytreatmentaninvitrostudy AT raquelosorio novelpastescontainingpolymericnanoparticlesfordentinhypersensitivitytreatmentaninvitrostudy AT estrellaosorio novelpastescontainingpolymericnanoparticlesfordentinhypersensitivitytreatmentaninvitrostudy AT antoniolmedinacastillo novelpastescontainingpolymericnanoparticlesfordentinhypersensitivitytreatmentaninvitrostudy AT manueltoledano novelpastescontainingpolymericnanoparticlesfordentinhypersensitivitytreatmentaninvitrostudy
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Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study

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