Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Abstract Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and...

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Autores principales:	Marie Hennebelle, Zhichao Zhang, Adam H. Metherel, Alex P. Kitson, Yurika Otoki, Christine E. Richardson, Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock, Liang Zhang, Richard P. Bazinet, Ameer Y. Taha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b35581fcdf054cdeaf34fbdef20d8aac
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spelling	oai:doaj.org-article:b35581fcdf054cdeaf34fbdef20d8aac2021-12-02T12:32:31ZLinoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission10.1038/s41598-017-02914-72045-2322https://doaj.org/article/b35581fcdf054cdeaf34fbdef20d8aac2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02914-7https://doaj.org/toc/2045-2322Abstract Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.Marie HennebelleZhichao ZhangAdam H. MetherelAlex P. KitsonYurika OtokiChristine E. RichardsonJun YangKin Sing Stephen LeeBruce D. HammockLiang ZhangRichard P. BazinetAmeer Y. TahaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Hennebelle Zhichao Zhang Adam H. Metherel Alex P. Kitson Yurika Otoki Christine E. Richardson Jun Yang Kin Sing Stephen Lee Bruce D. Hammock Liang Zhang Richard P. Bazinet Ameer Y. Taha Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
description	Abstract Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
format	article
author	Marie Hennebelle Zhichao Zhang Adam H. Metherel Alex P. Kitson Yurika Otoki Christine E. Richardson Jun Yang Kin Sing Stephen Lee Bruce D. Hammock Liang Zhang Richard P. Bazinet Ameer Y. Taha
author_facet	Marie Hennebelle Zhichao Zhang Adam H. Metherel Alex P. Kitson Yurika Otoki Christine E. Richardson Jun Yang Kin Sing Stephen Lee Bruce D. Hammock Liang Zhang Richard P. Bazinet Ameer Y. Taha
author_sort	Marie Hennebelle
title	Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_short	Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_full	Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_fullStr	Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_full_unstemmed	Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_sort	linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b35581fcdf054cdeaf34fbdef20d8aac
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Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

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