Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest

Abstract There is an ongoing debate why a trait like human menopause should have evolved. Adaptive explanations explain menopause with fitness benefits of ceasing reproduction, whereas non-adaptive explanations view it as an epiphenomenon. Here we present data in support of non-adaptive explanations...

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Auteurs principaux:	Susanne Huber, Martin Fieder
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Meiotic Arrest Human Meno Pausal Maximum Shelf-life Baleen Whales Time Oocytes Medicine R Science Q
Accès en ligne:	https://doaj.org/article/b3559e1fdf9c4f28a63ade279b397f35
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spelling	oai:doaj.org-article:b3559e1fdf9c4f28a63ade279b397f352021-12-02T15:08:11ZEvidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest10.1038/s41598-018-32502-22045-2322https://doaj.org/article/b3559e1fdf9c4f28a63ade279b397f352018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32502-2https://doaj.org/toc/2045-2322Abstract There is an ongoing debate why a trait like human menopause should have evolved. Adaptive explanations explain menopause with fitness benefits of ceasing reproduction, whereas non-adaptive explanations view it as an epiphenomenon. Here we present data in support of non-adaptive explanations of menopause suggesting a maximum shelf-life of oocytes. By analyzing the association between lifespan and age at reproductive senescence across 49 mammal species, we find that the positive association levels off in long lived species, indicating that the age at reproductive senescence has an upper limit. Only in baleen whales there seems to be no evidence for reproductive senescence. We suggest that apart from the baleen whales, the confinement of reproductive senescence in long-lived species may be the result of physiological constraints imposed by the long period of time oocytes remain inactive in an arrested phase of meiosis from their production in utero until ovulation. We therefore conclude that menopause may be an implication of the long duration of meiotic arrest caused by semelgametogenesis together with long lifespan.Susanne HuberMartin FiederNature PortfolioarticleMeiotic ArrestHuman Meno PausalMaximum Shelf-lifeBaleen WhalesTime OocytesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Meiotic Arrest Human Meno Pausal Maximum Shelf-life Baleen Whales Time Oocytes Medicine R Science Q
spellingShingle	Meiotic Arrest Human Meno Pausal Maximum Shelf-life Baleen Whales Time Oocytes Medicine R Science Q Susanne Huber Martin Fieder Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
description	Abstract There is an ongoing debate why a trait like human menopause should have evolved. Adaptive explanations explain menopause with fitness benefits of ceasing reproduction, whereas non-adaptive explanations view it as an epiphenomenon. Here we present data in support of non-adaptive explanations of menopause suggesting a maximum shelf-life of oocytes. By analyzing the association between lifespan and age at reproductive senescence across 49 mammal species, we find that the positive association levels off in long lived species, indicating that the age at reproductive senescence has an upper limit. Only in baleen whales there seems to be no evidence for reproductive senescence. We suggest that apart from the baleen whales, the confinement of reproductive senescence in long-lived species may be the result of physiological constraints imposed by the long period of time oocytes remain inactive in an arrested phase of meiosis from their production in utero until ovulation. We therefore conclude that menopause may be an implication of the long duration of meiotic arrest caused by semelgametogenesis together with long lifespan.
format	article
author	Susanne Huber Martin Fieder
author_facet	Susanne Huber Martin Fieder
author_sort	Susanne Huber
title	Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
title_short	Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
title_full	Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
title_fullStr	Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
title_full_unstemmed	Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
title_sort	evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3559e1fdf9c4f28a63ade279b397f35
work_keys_str_mv	AT susannehuber evidenceforamaximumshelflifeofoocytesinmammalssuggeststhathumanmenopausemaybeanimplicationofmeioticarrest AT martinfieder evidenceforamaximumshelflifeofoocytesinmammalssuggeststhathumanmenopausemaybeanimplicationofmeioticarrest
_version_	1718388274626560000

Evidence for a maximum “shelf-life” of oocytes in mammals suggests that human menopause may be an implication of meiotic arrest

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