Coevolution underlies GPCR-G protein selectivity and functionality
Abstract G protein-coupled receptors (GPCRs) regulate diverse physiological events, which makes them as the major targets for many approved drugs. G proteins are downstream molecules that receive signals from GPCRs and trigger cell responses. The GPCR-G protein selectivity mechanism on how they prop...
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Main Authors: | Min Jae Seo, Joongyu Heo, Kyunghui Kim, Ka Young Chung, Wookyung Yu |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Subjects: | |
Online Access: | https://doaj.org/article/b3576d08ff334e5cb17b5d4b1b84169a |
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