Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.

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Autores principales:	Cedric S. Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C. Wong, Kirill Tsyganov, Sarah Ghotb, Alison N. Graham, Feng Yan, Andrew A. Guirguis, Stefan E. Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B. Ting, David R. Powell, Stephen M. Jane, David J. Curtis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b35a3f8af939445d8e61e8a054430aae
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spelling	oai:doaj.org-article:b35a3f8af939445d8e61e8a054430aae2021-12-02T17:31:29ZRestricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells10.1038/s41467-018-06021-72041-1723https://doaj.org/article/b35a3f8af939445d8e61e8a054430aae2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06021-7https://doaj.org/toc/2041-1723Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.Cedric S. TremblayJesslyn SawSung Kai ChiuNicholas C. WongKirill TsyganovSarah GhotbAlison N. GrahamFeng YanAndrew A. GuirguisStefan E. SondereggerNicole LeePaul KalitsisJohn ReynoldsStephen B. TingDavid R. PowellStephen M. JaneDavid J. CurtisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cedric S. Tremblay Jesslyn Saw Sung Kai Chiu Nicholas C. Wong Kirill Tsyganov Sarah Ghotb Alison N. Graham Feng Yan Andrew A. Guirguis Stefan E. Sonderegger Nicole Lee Paul Kalitsis John Reynolds Stephen B. Ting David R. Powell Stephen M. Jane David J. Curtis Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
description	Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.
format	article
author	Cedric S. Tremblay Jesslyn Saw Sung Kai Chiu Nicholas C. Wong Kirill Tsyganov Sarah Ghotb Alison N. Graham Feng Yan Andrew A. Guirguis Stefan E. Sonderegger Nicole Lee Paul Kalitsis John Reynolds Stephen B. Ting David R. Powell Stephen M. Jane David J. Curtis
author_facet	Cedric S. Tremblay Jesslyn Saw Sung Kai Chiu Nicholas C. Wong Kirill Tsyganov Sarah Ghotb Alison N. Graham Feng Yan Andrew A. Guirguis Stefan E. Sonderegger Nicole Lee Paul Kalitsis John Reynolds Stephen B. Ting David R. Powell Stephen M. Jane David J. Curtis
author_sort	Cedric S. Tremblay
title	Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
title_short	Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
title_full	Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
title_fullStr	Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
title_full_unstemmed	Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
title_sort	restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b35a3f8af939445d8e61e8a054430aae
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Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

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