Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study

Li Wang, Yin Chen, Ying Yao, Yu Pan, Yi Sun Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brai...

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Autores principales:	Wang L, Chen Y, Yao Y, Pan Y, Sun Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Sleep deprivation Amplitude of low frequency fluctuation Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b35a807984a447f68f4be68bce038e65
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spelling	oai:doaj.org-article:b35a807984a447f68f4be68bce038e652021-12-02T06:08:16ZSleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study1178-2021https://doaj.org/article/b35a807984a447f68f4be68bce038e652016-04-01T00:00:00Zhttps://www.dovepress.com/sleep-deprivation-disturbed-regional-brain-activity-in-healthy-subject-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Li Wang, Yin Chen, Ying Yao, Yu Pan, Yi Sun Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated “task-positive” network, and the advanced cognitive function brain areas. Keywords: sleep deprivation, amplitude of low-frequency fluctuation, default-mode network, functional magnetic resonance imagingWang LChen YYao YPan YSun YDove Medical PressarticleSleep deprivationAmplitude of low frequency fluctuationFunctional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 801-807 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sleep deprivation Amplitude of low frequency fluctuation Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Sleep deprivation Amplitude of low frequency fluctuation Functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang L Chen Y Yao Y Pan Y Sun Y Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
description	Li Wang, Yin Chen, Ying Yao, Yu Pan, Yi Sun Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated “task-positive” network, and the advanced cognitive function brain areas. Keywords: sleep deprivation, amplitude of low-frequency fluctuation, default-mode network, functional magnetic resonance imaging
format	article
author	Wang L Chen Y Yao Y Pan Y Sun Y
author_facet	Wang L Chen Y Yao Y Pan Y Sun Y
author_sort	Wang L
title	Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
title_short	Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
title_full	Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
title_fullStr	Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
title_full_unstemmed	Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
title_sort	sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b35a807984a447f68f4be68bce038e65
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Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study

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