A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE

The article presents some data concerning antigenic and immunogenic properties of the lethal heat-stable toxin (HST) from Yersinia pseudotuberculosis, a protein with molecular weight of 45 kDa. The mice,following double immunization with HST at a dose of 0.1 mg per mouse, displayed higher antibody p...

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Autores principales:	A. V. Tsybulsky, N. F. Timchenko, E. Ya. Kostetsky, N. S. Vorobieva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	yersinia pseudotuberculosis heat-stable toxin immunogenicity protective effect cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b35e429da7f54f82b2763d61b9e35a26
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spelling	oai:doaj.org-article:b35e429da7f54f82b2763d61b9e35a262021-11-18T08:03:44ZA STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE1563-06252313-741X10.15789/1563-0625-2014-3-227-236https://doaj.org/article/b35e429da7f54f82b2763d61b9e35a262014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/688https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article presents some data concerning antigenic and immunogenic properties of the lethal heat-stable toxin (HST) from Yersinia pseudotuberculosis, a protein with molecular weight of 45 kDa. The mice,following double immunization with HST at a dose of 0.1 mg per mouse, displayed higher antibody production, in comparison with a dose of 0.01 mg/mouse. The appropriate differences were revealed with regard ofleukocyte responses, i.e., development of leukopenia, neutropenia, lymphopenia upon immunization with the 0.01 mg of HST per mouse, whereas leukocytosis, and increase in lymphocytes and monocytes was detected after a dose of 0.1 mg/mouse. We detected some doseependent differences in cytokine-modulating activity. I.e., at HST dose of 0.01 mg per mouse, we detected mostly proinflammatory, acutehase responses, whereas a dose of 0.1 mg/mice caused induction of . IFNγ and cytokines promoting lymphocyte proliferation and antibody production by day +17. Upon double immunization of mice, the toxin showed protective properties when injecting them with lethal dose of Y. pseudotuberculosis. A lagging activation of antibody producers duringHST response suggests a need for searching effective adjuvant tools of enhancement and acceleration of specific humoral immune reactions against this antigen.A. V. TsybulskyN. F. TimchenkoE. Ya. KostetskyN. S. VorobievaSPb RAACIarticleyersinia pseudotuberculosisheat-stable toxinimmunogenicityprotective effectcytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 227-236 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	yersinia pseudotuberculosis heat-stable toxin immunogenicity protective effect cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	yersinia pseudotuberculosis heat-stable toxin immunogenicity protective effect cytokines Immunologic diseases. Allergy RC581-607 A. V. Tsybulsky N. F. Timchenko E. Ya. Kostetsky N. S. Vorobieva A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
description	The article presents some data concerning antigenic and immunogenic properties of the lethal heat-stable toxin (HST) from Yersinia pseudotuberculosis, a protein with molecular weight of 45 kDa. The mice,following double immunization with HST at a dose of 0.1 mg per mouse, displayed higher antibody production, in comparison with a dose of 0.01 mg/mouse. The appropriate differences were revealed with regard ofleukocyte responses, i.e., development of leukopenia, neutropenia, lymphopenia upon immunization with the 0.01 mg of HST per mouse, whereas leukocytosis, and increase in lymphocytes and monocytes was detected after a dose of 0.1 mg/mouse. We detected some doseependent differences in cytokine-modulating activity. I.e., at HST dose of 0.01 mg per mouse, we detected mostly proinflammatory, acutehase responses, whereas a dose of 0.1 mg/mice caused induction of . IFNγ and cytokines promoting lymphocyte proliferation and antibody production by day +17. Upon double immunization of mice, the toxin showed protective properties when injecting them with lethal dose of Y. pseudotuberculosis. A lagging activation of antibody producers duringHST response suggests a need for searching effective adjuvant tools of enhancement and acceleration of specific humoral immune reactions against this antigen.
format	article
author	A. V. Tsybulsky N. F. Timchenko E. Ya. Kostetsky N. S. Vorobieva
author_facet	A. V. Tsybulsky N. F. Timchenko E. Ya. Kostetsky N. S. Vorobieva
author_sort	A. V. Tsybulsky
title	A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
title_short	A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
title_full	A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
title_fullStr	A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
title_full_unstemmed	A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE
title_sort	study of immunogenic and protective properties of the heat-stable lethal toxin of yersinia pseudotuberculosis and its effects upon hematological and blood cytokine parameters of laboratory mice
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b35e429da7f54f82b2763d61b9e35a26
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_version_	1718422442230153216

A STUDY OF IMMUNOGENIC AND PROTECTIVE PROPERTIES OF THE HEAT-STABLE LETHAL TOXIN OF YERSINIA PSEUDOTUBERCULOSIS AND ITS EFFECTS UPON HEMATOLOGICAL AND BLOOD CYTOKINE PARAMETERS OF LABORATORY MICE

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